Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 543.00 | |
100 mg | In stock | $ 783.00 | |
500 mg | In stock | $ 1,620.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial |
Targets&IC50 | α7 nAChR:10.8 nM (Ki, for rat α7 receptors), α7 nAChR:16.7 nM (Ki, for human α7 receptors), 5-HT3 receptor:150 nM (Ki) |
In vivo | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function. |
Synonyms | A 582941 |
Molecular Weight | 353.29 |
Formula | C17H22Cl2N4 |
CAS No. | 848591-90-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (196.17 mM)
You can also refer to dose conversion for different animals. More
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A-582941 dihydrochloride 848591-90-2 GPCR/G Protein Neuroscience 5-HT Receptor AChR A-582941 Dihydrochloride Serotonin Receptor psychiatric 5-HT3 deficits A 582941 Dihydrochloride Inhibitor A582941 dihydrochloride A582941 Dihydrochloride A-582941 Nicotinic acetylcholine receptors neurodegenerative A 582941 nAChR A582941 5-hydroxytryptamine Receptor partial cognitive A 582941 dihydrochloride inhibit inhibitor