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PHA 543613

Catalog No. T23145 CAS 478149-53-0

PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.

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PHA 543613, CAS 478149-53-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 46.00
5 mg	In stock	$ 109.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 678.00
100 mg	In stock	$ 995.00
500 mg	In stock	$ 2,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 99.48%

ee: 100%

Purity: 99%

Biological Description

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Storage & Solubility Information

Description	PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
Targets&IC50	α7 nAChR:8.8 nM (Ki)
In vivo	In rats, PHA-543613 (0.3 mg/kg) reverses Scopolamine-induced short-term memory deficits[2]. Intraperitoneal injection of PHA-543613 (4 and 12 mg/kg) increases p-Akt and decreases p-GSK-3 and CC3 expressions in the ipsilateral hemisphere. PHA-543613 reduces neuronal cell death in the perihematomal area[3].

Molecular Weight	271.31
Formula	C15H17N3O2
CAS No.	478149-53-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (829.3 mM), Sonication is recommended.

H2O: < 30.78 mg/mL

References and Literature

1. Donn G Wishka, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. [Content Brief] 2. Nóra Bruszt, et al. Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task. Psychopharmacology (Berl). 2021 Nov;238(11):3273-3281. 3. Krafft PR, et al. α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library

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Keywords

PHA 543613 478149-53-0 Neuroscience Others AChR PHA543613 PHA-543613 PHA 543613 hydrochloride inhibitor inhibit

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