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GSK-872

Name: GSK-872
Brand: TargetMol
SKU: T4074
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4074Cas No. 1346546-69-7

Alias GSK'872, GSK872, GSK2399872A

GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).

GSK-872

🥰Excellent

Purity: 99.94%

Catalog No. T4074Alias GSK'872, GSK872, GSK2399872ACas No. 1346546-69-7

GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$68	In Stock
10 mg	$116	In Stock
25 mg	$188	In Stock
50 mg	$321	In Stock
100 mg	$493	In Stock
200 mg	$706	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock

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Batch Information

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Purity:99.94%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
Targets&IC50	RIP3K:1.8 nM
In vitro	GSK872 (1 μM) has no inhibition for most of 300 human protein kinases tested. It fails to inhibit RIP1 kinase. In HT-29 cells, GSK872 concentration-dependently blocks TNF-induced necroptosis. In cell-based assays, there is a 100- to 1000-fold shift in the IC50 compared to the cell-free biochemical assays. GSK872 inhibits DAI- or TLR3-induced (RIP1-independent) death. It induces caspase activation and then induces apoptotic cell death[1].
In vivo	In compared with no treatment after ischemic injury in vivo, GSK872 can significantly reduce HIF-1α expression [3].
Synonyms	GSK'872, GSK872, GSK2399872A

Chemical Properties

Molecular Weight	383.49
Formula	C₁₉H₁₇N₃O₂S₂
Cas No.	1346546-69-7
Smiles	CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1
Relative Density.	1.395 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 141 mg/mL (367.68 mM), Sonication is recommended.

Ethanol: 38 mg/mL (99.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6076 mL	13.0381 mL	26.0763 mL	130.3815 mL
5 mM	0.5215 mL	2.6076 mL	5.2153 mL	26.0763 mL
10 mM	0.2608 mL	1.3038 mL	2.6076 mL	13.0381 mL
20 mM	0.1304 mL	0.6519 mL	1.3038 mL	6.5191 mL
50 mM	0.0522 mL	0.2608 mL	0.5215 mL	2.6076 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc