compound — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3521	γ-Secretase-IN-1	Compound E	Beta Amyloid , Gamma-secretase
	γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.		Beta Amyloid , Gamma-secretase
T4356	POL1-IN-1	Compound 3A	DNA/RNA Synthesis
	POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.		DNA/RNA Synthesis
T9184L	Compound 3344 hydrochloride	4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base),Compound 3344 hydrochloride (2368246-78-8 free base)	Ras
	Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.		Ras
T8555	Neuraminidase-IN-1	Novel NA Inhibitor,Compound Y-1	Others , Influenza Virus
	Neuraminidase-IN-1 (Compound Y-1) is a novel neuraminidase inhibitor.		Others , Influenza Virus
T9544	Compound 1T-0216		Others
	Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation.		Others
T3586	Compound 401	2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	DNA-PK
	Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.		DNA-PK
T9545	Compound 1T-0219 (SC)		FAK
	Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylati...		FAK
T13623	Compound 48/80 trihydrochloride	C48/80 trihydrochloride	Phospholipase
	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and hista...		Phospholipase
T35398	MINA53 inhibitor (Compound 10)		Others
	MINA53 inhibitor (Compound 10) is an inhibitor of MINA53.		Others
T9853	STING activator Compound 53		STING
	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons...		STING
T77771	Compound 10w		Others
	Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.		Others
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T3964	Glutaminase C-IN-1	Compound 968,Glutaminase Inhibitor Compound 968	Glutaminase
	Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.		Glutaminase
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T3587	NOD-IN-1	Compound 4	NOD-like Receptor (NLR) , NOD
	NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.		NOD-like Receptor (NLR) , NOD
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	Compound W	Gamma-secretase
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).		Gamma-secretase
T0274	Cinoxacin	Compound 64716	Topoisomerase , Antibacterial , Antibiotic
	Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.		Topoisomerase , Antibacterial , Antibiotic
T38387	Compound C108		GTPase
	Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.		GTPase
T50125	Compound C749
	Compound C749 is a useful organic compound for research related to life sciences. The catalog number is T50125 and the CAS number is 57-03-4.
T77580	IK-930	compound I-32	YAP
	IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.		YAP