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Compound 401

Catalog No. T3586 CAS 168425-64-7

Synonyms: 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.

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Compound 401, CAS 168425-64-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 75.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 377.00
100 mg	In stock	$ 559.00
500 mg	In stock	$ 1,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 99.76%

Purity: 99.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
Targets&IC50	DNA-PK:0.28 μM
In vitro	Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively).

Synonyms	2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one
Molecular Weight	281.31
Formula	C16H15N3O2
CAS No.	168425-64-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.45 mg/mL (19.39 mM), Sonification is recommended

References and Literature

1. Ballou LM,et al. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. Epub 2007 Jun 11.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Metabolism Compound Library Target-Focused Phenotypic Screening Library Antioxidant Compound Library Kinase Inhibitor Library Anti-Obesity Compound Library Anti-Breast Cancer Compound Library Glycometabolism Compound Library Glutamine Metabolism Compound Library Antidepressant Compound Library

Related Products

Related compounds with same targets

IC 86621 LY294002 PI-3065 NU6027 BAY-8400 PI3K-IN-1 Pilaralisib analogue ZL-2201

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Compound 401 168425-64-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one Compound401 DNA-dependent protein kinase Compound-401 inhibit Inhibitor inhibitor

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