Home Tools
Log in
Cart

POL1-IN-1

Catalog No. T4356   CAS 1822358-25-7
Synonyms: Compound 3A

POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
POL1-IN-1 Chemical Structure
POL1-IN-1, CAS 1822358-25-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 97.00
10 mg In stock $ 147.00
25 mg In stock $ 228.00
50 mg In stock $ 343.00
100 mg In stock $ 497.00
1 mL * 10 mM (in DMSO) In stock $ 105.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
In vivo Corynoxine promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Corynoxine promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Corynoxine induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].
Synonyms Compound 3A
Molecular Weight 356.42
Formula C21H20N6
CAS No. 1822358-25-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.57 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Chen L L , Song J X , Lu J H , et al. Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway[J]. Journal of Neuroimmune Pharmacology, 2014, 9(3):380-387. 2. Sakakibara I, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.

Related compound libraries

This product is contained In the following compound libraries:
Cell Cycle Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library Inhibitor Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
DMT-dU-CE Phosphoramidite Sorivudine 6-Mercaptopurine hydrate 5-Methylcytosine RI-2 SMN-C3 Cholesteryl Hemisuccinate Rifapentine

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

POL1-IN-1 1822358-25-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis POL1 IN 1 POL-1-IN-1 proliferation inhibit cancer Inhibitor cell transcription Compound 3A POL1IN1 inhibitor

 

TargetMol