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NOD-IN-1

Catalog No. T3587 CAS 132819-92-2

Synonyms: Compound 4

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.

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NOD-IN-1, CAS 132819-92-2

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Purity: 98%

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Description	NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
Targets&IC50	NOD2:6.45 μM, NOD1:5.74 μM
In vitro	NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets[1].
Cell Research	NOD-IN-1 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. An MTS assay in which the proliferation rates of HEK-Blue NOD1 cells are measured in the presence of Noditinib-1 and of the synthesized potential NOD1 inhibitor NOD-IN-1 is employed to screen these compounds for potential cytotoxicity. Cells are treated for 24 h with the compound of interest at concentrations of up to 25 μM. Comparison of the resulting metabolic activities with that of the untreated control showed that all compounds are well tolerated by HEK-Blue NOD1 cells, since their residual metabolic activities do not fall below 80% at the maximum concentration tested[1].

Synonyms	Compound 4
Molecular Weight	343.4
Formula	C18H17NO4S
CAS No.	132819-92-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kecek Plesec K, et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234.

Related compound libraries

This product is contained In the following compound libraries：

HIF-1 Signaling Pathway Compound Library Anti-Parkinson's Disease Compound Library Inhibitor Library Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Nonsteroidal Anti-Inflammatory Compound Library Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library

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Keywords

NOD-IN-1 132819-92-2 NF-Kb信号通路免疫与炎症 NOD NOD-like Receptor (NLR) NODIN1 Compound 4 inhibit NOD IN 1 Inhibitor inhibitor

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