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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13114 | CCR2 antagonist 4 | Teijin compound 1 | CCR |
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM). | |||
T17214 | Valencene | NSC 148969,NSC-148969,NSC148969 | Others , Antioxidant , NF-κB |
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, an... | |||
T4411 | DAMGO TFA (78123-71-4(Free base)) | Opioid Receptor | |
Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food int... | |||
T24270 | KS370G | KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide | |
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... | |||
T9113 | Myristicin | Myristicine | IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase |
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ... | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
T32353 | K 76 Carboxylic acid | K76 Carboxylic acid,K-76 Carboxylic acid | |
K 76 Carboxylic acid effectively blocks human complement from forming tumor cell chemokines. | |||
T22477 | (±)-AMG 487 | Others | |
AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively). | |||
T41086 | IDR-1 | ||
IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 ... | |||
T61621 | IMMH001 | ||
IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the lev... | |||
T73424 | GA-O-06 | ||
GA-O-06, an 18β-Glycyrrhetinic acid derivative, serves as a potent antimicrobial and anti-inflammatory agent. It achieves its anti-inflammatory effects by inhibiting NO, pro-inflammatory cytokines, and chemokines, while ... | |||
T78552 | PB118 | ||
PB118 has the capacity to effectively clear Aβ deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl α-tubulin levels, modulate various inflammation-associated cytokines an... | |||
T36623 | Antileukinate | ||
Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutro... | |||
TN5149 | Tirotundin | NF-κB , COX , PPAR | |
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory me... | |||
T73423 | GA-O-02 | ||
GA-O-02, an 18β-Glycyrrhetinic acid (GA) derivative, functions as a powerful antimicrobial and anti-inflammatory agent. This compound inhibits NO, pro-inflammatory cytokines, and chemokines to exert its anti-inflammatory... | |||
TN3983 | Ergosta-7,22-dien-3-one | NO Synthase , LTR | |
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory properties, it stimulates nitric oxide production, induces gene expr... | |||
T79256 | DPP-4-IN-8 | ||
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM. It inhibits the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells and... | |||
T81738 | Murabutide | ||
Murabutide, a safe synthetic immunomodulator, diminishes the expression of CD4 and CCR5 receptors and promotes the secretion of high levels of beta-chemokines, thereby enhancing nonspecific resistance to viral infections... | |||
T68182 | 3-Hydroxykynurenamine | ||
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the... | |||
T37861 | Talabostat | ||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ... |