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DAMGO TFA (78123-71-4(Free base))

Catalog No. T4411   CAS T4411

Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food intake of rats.

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DAMGO TFA (78123-71-4(Free base)) Chemical Structure
DAMGO TFA (78123-71-4(Free base)), CAS T4411
Pack Size Availability Price/USD Quantity
1 mg Inquiry $ 57.00
2 mg Inquiry $ 98.00
5 mg Inquiry $ 173.00
10 mg Inquiry $ 298.00
25 mg Inquiry $ 567.00
50 mg Inquiry $ 776.00
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Purity: 99.76%
Purity: 98.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food intake of rats.
Targets&IC50 μ-opioid receptor:NA
Molecular Weight 627.6
Formula C28H36F3N5O8
CAS No. T4411

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 110 mg/mL

DMSO: 115 mg/mL

TargetMolReferences and Literature

1. Onogi T,etal.DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.FEBS Lett. 1995 Jan 2;357(1):93-7. 2. Selve N,etal.Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats.Brain Res. 1996 Oct 7;735(2):177-87. 3. Szabó G,etal.Long-lasting antinociceptive effect of DAMGO chloromethyl ketone in rats.Peptides. 1999 Nov;20(11):1321-6. 4. Rubovitch V,etal.The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway.Brain Res Mol Brain Res. 2003 Feb 20;110(2):261-6. 5. Happel C,etal.DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1.J Leukoc Biol. 2008 Apr;83(4):956-63.

Related compound libraries

This product is contained In the following compound libraries:
TGF-beta/Smad Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Parkinson's Disease Compound Library Target-Focused Phenotypic Screening Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Anti-Neurodegenerative Disease Compound Library

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Keywords

DAMGO TFA (78123-71-4(Free base)) T4411 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor DAMGO TFA (78123714(Free base)) DAMGO TFA (78123 71 4(Free base)) inhibitor inhibit

 

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