antitumour — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5521	Bropirimine	U-54461	TLR
	Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.		TLR
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.		Apoptosis , Microtubule Associated
Fr12290	4-Methoxycoumarine		Others
	4-Methoxycoumarine has antitumour effects.		Others
T27603	INCB3619	INCB-3619,INCB 3619	Immunology/Inflammation related
	INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.		Immunology/Inflammation related
T77732L	HFY-4A HCL (2094810-82-7 Free base)
	HFY-4A HCL is a novel HDAC inhibitor.HFY-4A HCL has antitumour activity and has shown antiproliferative activity in breast cancer cells.
TN1757	Hypophyllanthin		Potassium Channel , Calcium Channel , P-gp
	Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.		Potassium Channel , Calcium Channel , P-gp
T67884	β-catenin modulator IIa-661		Wnt/beta-catenin
	β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.		Wnt/beta-catenin
TNU0031	5-Hydroxyuridine	OHUrd	Nucleoside Antimetabolite/Analog
	5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumour activity, showing cytotoxicity against human colon adenocarcinoma cell lines.		Nucleoside Antimetabolite/Analog
T7468	(-)-α-Terpineol	α-Terpineol	Others
	(-)-α-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway		Others
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K
T5335	S-Gboxin		Others
	S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM).		Others
T69644	DUN73423	RET-IN-21	c-RET
	DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.		c-RET
TMA2253	Triumbelletin		Others
	Triumbelletin is a tricoumarin rhamnopyranoside obtained from Wikstroemia indica with antitumour activity for the study of tumours.		Others
T61428	4-PQBH		Others
	4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH inhibits xenograft tumours through Nur77-mediated endoplasmic stress and autophagy by broadly inducing cysteoaspartase-independent cytoplasmic vacuol...		Others
T5448	Clanfenur		Others
	Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.		Others
T29541	AC265347	AC-265347	CaSR
	AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud...		CaSR
T29857	Alethine	β-Alethine	TNF
	Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells.		TNF
T15373	Gboxin		ATPase , Mitochondrial Metabolism
	Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.		ATPase , Mitochondrial Metabolism
T71553	Ainsliadimer A
	Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.