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INCB3619

Catalog No. T27603 CAS 791826-72-7

Synonyms: INCB-3619, INCB 3619

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

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INCB3619, CAS 791826-72-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 692.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00

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Purity: 100%

ee: 100%

Purity: 100%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
Targets&IC50	Heregulin:0.24 μM
In vitro	The dual ADAM inhibitor INCB3619 inhibits heregulin cleavage with an IC50 value of 0.24 μM[1].Treating A549 cells in serum-free culture with varying concentrations of gefitinib and INCB3619 (2-10 µM) for 96 hours revealed that INCB3619 sensitizes A549 cells to gefitinib[1].
In vivo	INCB3619 was administered subcutaneously using ALZET osmotic pumps at doses of 30 or 60 mg/kg/day for 14 days. The results showed that the ADAM inhibitor INCB3619 inhibited gefitinib-resistant HER3 autocrine mechanism, exerting antitumor activity in vivo, and sensitizing tumors to chemotherapy drugs[1].

Synonyms	INCB-3619, INCB 3619
Molecular Weight	413.47
Formula	C22H27N3O5
CAS No.	791826-72-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10(1):39-50. 2. Wiernik A, Foley B, Zhang B, Verneris MR, Warlick E, Gleason MK, Ross JA, Luo X, Weisdorf DJ, Walcheck B, Vallera DA, Miller JS. Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition. Clin Cancer Res. 2013 Jul 15;19(14):3844-55. doi: 10.1158/1078-0432.CCR-13-0505. PubMed PMID: 23690482; PubMed Central PMCID: PMC3715574. 3. Floyd DH, Kefas B, Seleverstov O, Mykhaylyk O, Dominguez C, Comeau L, Plank C, Purow B. Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch. Neuro Oncol. 2012 Oct;14(10):1215-26. PubMed PMID: 22962413; PubMed Central PMCID: PMC3452340. 4. Witters L, Scherle P, Friedman S, Fridman J, Caulder E, Newton R, Lipton A. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 1;68(17):7083-9. doi: 10.1158/0008-5472.CAN-08-0739. PubMed PMID: 18757423.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

INCB3619 791826-72-7 Immunology/Inflammation Immunology/Inflammation related INCB-3619 INCB 3619 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.