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Gboxin

Catalog No. T15373   CAS 2101315-36-8

Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.

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Gboxin Chemical Structure
Gboxin, CAS 2101315-36-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 55.00
2 mg In stock $ 81.00
5 mg In stock $ 126.00
10 mg In stock $ 207.00
25 mg In stock $ 448.00
50 mg In stock $ 658.00
100 mg In stock $ 938.00
500 mg In stock $ 1,890.00
1 mL * 10 mM (in DMSO) In stock $ 148.00
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Purity: 100%
Purity: 99.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
In vitro Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.?Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells.?Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane, and it inhibits the activity of F0F1 ATP synthase.?Gboxin-resistant cells require a functional mitochondrial permeability transition pore that regulates pH and thus impedes the accumulation of Gboxin in the mitochondrial matrix.?Administration of a metabolically stable Gboxin analogue inhibits glioblastoma allografts and patient-derived xenografts.?Gboxin toxicity extends to established human cancer cell lines of diverse organ origin, and shows that the increased proton gradient and pH in cancer cell mitochondria is a mode of action that can be targeted in the development of antitumour reagents.
Molecular Weight 392.96
Formula C22H33ClN2O2
CAS No. 2101315-36-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (25.45 mM), sonification is recommended.

DMSO: 32.5 mg/mL (82.71 mM), sonification is recommended.

TargetMolReferences and Literature

1. Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Anti-Cancer Active Compound Library Apoptosis Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Ion Channel Inhibitor Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library

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Keywords

Gboxin 2101315-36-8 Membrane transporter/Ion channel Metabolism ATPase Mitochondrial Metabolism ATP Synthase Inhibitor inhibit inhibitor

 

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