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PARP/PI3K-IN-1

PARP/PI3K-IN-1
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
Catalog No. T12365Cas No. 2337386-47-5
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Purity:99.59%
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PARP/PI3K-IN-1

Catalog No. T12365Cas No. 2337386-47-5
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
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Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$255In Stock
10 mg$396In Stock
25 mg$689In Stock
50 mg$1,070In Stock
100 mg$1,450In Stock
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Product Introduction

Bioactivity
Description
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic and lung cancers.
Targets&IC50
PARP1:8.22 (pIC50), PI3Kγ:6.08 (pIC50), PI3Kα:8.25 (pIC50), PARP2:8.44 (pIC50), PI3Kβ:6.54 (pIC50), PI3Kδ:8.13 (pIC50)
In vitro
PARP/PI3K-IN-1 (1 μM; 72 h) decreased the levels of self-phosphorylation of AKT and S6, while increasing the phosphorylation levels of ERK following treatment, indicating the inhibition of the PI3K pathway and activation of the ERK pathway by PARP/PI3K-IN-1, resulting in significantly increased apoptosis.[1]. In BRCA-deficient cells, PARP/PI3K-IN-1 not only exhibits significant inhibitory activity against HCC1937 and HCT116, but also demonstrates anti-proliferative activity against MDA-MB-231 and MDA-MB-468 [1].
In vivo
PARP/PI3K-IN-1 (IP; 50 mg/kg; treatment for 34 days) significantly inhibits tumor growth[1].
Chemical Properties
Molecular Weight660.62
FormulaC33H28F4N8O3
Cas No.2337386-47-5
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (121.10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5137 mL7.5686 mL15.1373 mL75.6865 mL
5 mM0.3027 mL1.5137 mL3.0275 mL15.1373 mL
10 mM0.1514 mL0.7569 mL1.5137 mL7.5686 mL
20 mM0.0757 mL0.3784 mL0.7569 mL3.7843 mL
50 mM0.0303 mL0.1514 mL0.3027 mL1.5137 mL
100 mM0.0151 mL0.0757 mL0.1514 mL0.7569 mL

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