antifibrotic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9592	OATD-01		Others
	OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).		Others
T7436	Cilofexor		FXR , Autophagy
	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.		FXR , Autophagy
T1738	Taxifolin	(+)-Taxifolin,Dihydroquercetin,(+)-Dihydroquercetin	VEGFR , TNF , Tyrosinase , Adrenergic Receptor , Autophagy
	Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.		VEGFR , TNF , Tyrosinase , Adrenergic Receptor , Autophagy
T28578	Ro24-7429	Ro 24-7429,Ro-24-7429,Ro 247429	HIV Protease
	Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.		HIV Protease
T9947	GW-6604		PAI-1 , ALK , TGF-beta/Smad
	GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.		PAI-1 , ALK , TGF-beta/Smad
T13473	αvβ1 integrin-IN-1		Integrin
	αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.		Integrin
T67773	IMSs inhibitor S12 Perchlorate		Others
	IMSs inhibitor S12 Perchlorate has antifibrotic and anticancer properties.		Others
T14895	Tanzisertib	CC-930	JNK
	Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.		JNK
T60162	1H-Pyrazole-5-carboxamide, 4-(5-chloro-2-furanyl)-1,3-bis(2,4-difluorophenyl)-4,5-dihydro-5-methyl-N-[(4-methyl-2-morpholinyl)methyl]		Others
	1H-Pyrazole-5-carboxamide, 4-(5-chloro-2-furanyl)-1,3-bis(2,4-difluorophenyl)-4,5-dihydro-5-methyl-N-[(4-methyl-2-morpholinyl)methyl] is an antifibrotic agent.		Others
T62882	Ezurpimtrostat hydrochloride
	Ezurpimtrostat hydrochloride (compound 2-3) is an orally active antifibrotic agent that significantly reduces liver fibrosis in rats with DEN (diethylnitrosamine) cirrhosis. CTSB, CTSL and CTSD related diseases.
T76856	Andecaliximab	GS-5745	MMP , Virus Protease
	Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used ...		MMP , Virus Protease
T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T39933	Bexotegrast	PLN-74809	Integrin
	Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibits αvβ6 and αvβ1-induced activation of TGF-β, and can be used for the study of idiopathic pulmo...		Integrin
T2795	Amygdalin	Laetrile	Others
	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce...		Others
T1311	4-aminobenzoic acid	PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid	Endogenous Metabolite
	4-aminobenzoic acid (para-Aminobenzoic acid) is an organic acid with UV absorption and antifibrotic properties. When exposed to light, 4-aminobenzoic acid absorbs UV light and emits excess energy via a photochemical reac...		Endogenous Metabolite
T67961	Safironil		Others
	safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin le...		Others
T40943	EMD527040
	EMD527040 is a powerful and highly specific αvβ6 antagonist, exhibiting notable antifibrotic properties. It is suitable for conducting research on carcinoma and liver fibrosis.
T39739	Bersiporocin
	Bersiporocin, a prolyl-tRNA synthetase inhibitor, demonstrates potent activity with an IC50 of ≤100 nM against phosphoribosylpyrophosphate synthetase (PRS). This compound proves valuable for antifibrotic research.
T10862	Collagen proline hydroxylase inhibitor		Others
	Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.		Others