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Amygdalin

Catalog No. T2795 CAS 29883-15-6

Synonyms: Laetrile

Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of Amygdalin or HSYA. Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.

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Amygdalin, CAS 29883-15-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 42.00
100 mg	In stock	$ 54.00
200 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 100%

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Description	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of Amygdalin or HSYA. Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
In vitro	Amygdalin exhibits antitumor properties, with studies showing progress in elucidating its mechanism of action[1]. Specifically, amygdalin downregulates genes related to the cell cycle, including exonuclease 1, ATP-binding cassette sub-family F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis has demonstrated that amygdalin treatment leads to reduced mRNA levels of these genes in SNU-C4 human colon cancer cells[2].
In vivo	Amygdalin demonstrates efficacy in mitigating inflammatory pain, serving as an analgesic endowed with anti-nociceptive and anti-inflammatory properties. Administered intramuscularly, it notably diminishes formalin-induced tonic pain in the initial acute phase (the initial 10 min after formalin injection) as well as the persistent, late phase (10-30 min post-formalin injection). Moreover, amygdalin's pain-reduction effect escalates with increasing doses, up to a threshold of less than 1 mg/kg during the latter period[3].
Cell Research	Cell viability is determined by MTT assay. Cells are seeded in triplicate at a concentration of 1×105 cells/well on a 96-well plate. SNU-C4 cells are treated with amygdalin at concentrations of 0.25, 0.5, 2.5, and 5 mg/mL for 24 h. After MTT is added to each group, the cells are incubated for 4 h. Then, they are further incubated for 1 h, including the solution in which MTT is dissolved[2].
Source	Natural Products > Rosaceae > apricot

Synonyms	Laetrile
Molecular Weight	457.43
Formula	C20H27NO11
CAS No.	29883-15-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 84 mg/mL (183.6 mM)

H2O: 45.74mg/mL(100mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Song Z, et al. Advanced research on anti-tumor effects of amygdalin. J Cancer Res Ther. 2014 Aug;10 Suppl 1:3-7. 2. Park HJ,et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 7;11(33):5156-61. 3. Hwang HJ,et al. Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biol Pharm Bull. 2008 Aug;31(8):1559-64.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-Prostate Cancer Compound Library Anti-Aging Compound Library PBCRBS Traditional Chinese Medicine Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Metabolite Library

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Amygdalin 29883-15-6 Others Inhibitor inhibit Laetrile inhibitor

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