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Ro24-7429

Name: Ro24-7429
Brand: TargetMol
SKU: T28578
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28578Cas No. 139339-45-0

Alias Ro-24-7429, Ro 24-7429, Ro 247429

Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.

Ro24-7429

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Purity: 99.85%

Catalog No. T28578Alias Ro-24-7429, Ro 24-7429, Ro 247429Cas No. 139339-45-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$533	In Stock	In Stock
50 mg	$768	In Stock	In Stock
100 mg	$1,080	In Stock	In Stock
500 mg	$3,028	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$226	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.
Targets&IC50	C8166 cells:0.7 μM
In vitro	Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2].
In vivo	Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1].
Synonyms	Ro-24-7429, Ro 24-7429, Ro 247429

Chemical Properties

Molecular Weight	272.73
Formula	C₁₄H₁₃ClN₄
Cas No.	139339-45-0
Smiles	CNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (513.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6666 mL	18.3332 mL	36.6663 mL	183.3315 mL
5 mM	0.7333 mL	3.6666 mL	7.3333 mL	36.6663 mL
10 mM	0.3667 mL	1.8333 mL	3.6666 mL	18.3332 mL
20 mM	0.1833 mL	0.9167 mL	1.8333 mL	9.1666 mL
50 mM	0.0733 mL	0.3667 mL	0.7333 mL	3.6666 mL
100 mM	0.0367 mL	0.1833 mL	0.3667 mL	1.8333 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc