acetylation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T80947	Tri-GalNAc-COOH (acetylation)		LYTACs
	Tri-GalNAc-COOH acetylation represents the acetylated derivative of tri-galactosamine (tri-GalNAc-COOH), utilized in the synthesis of lysosome targeting chimeras (LYTAC).		LYTACs
T6421	BRD73954		HDAC
	BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.		HDAC
T11563	Histone Acetyltransferase Inhibitor II		Epigenetic Reader Domain , Histone Acetyltransferase
	Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.		Epigenetic Reader Domain , Histone Acetyltransferase
T11807	L002		Others , Histone Acetyltransferase , STAT
	L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...		Others , Histone Acetyltransferase , STAT
T14991	CMS-121	CMS121	Acetyl-CoA Carboxylase
	CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotect...		Acetyl-CoA Carboxylase
T13996	1-Naphthohydroxamic acid		HDAC
	1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d...		HDAC
T5347	CXD101	CXD-101	HDAC
	CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II		HDAC
T1818	Tenovin-6	Tenovin 6	Dehydrogenase , Sirtuin , Autophagy
	Tenovin-6 is a p53 transcriptional activity agonist.		Dehydrogenase , Sirtuin , Autophagy
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T23820	BRD32048	BRD-32048,BRD 32048	DNA/RNA Synthesis
	BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.		DNA/RNA Synthesis
T8480	Tenovin-6 Hydrochloride		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
T4328	OSS_128167	SIRT6-IN-1	HBV , Sirtuin
	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).		HBV , Sirtuin
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial
T60065	WAY-118959-A		Microtubule Associated
	WAY-118959-A is a potential microtubule acetylation inhibitor.		Microtubule Associated
T0538	3-Methylindolin-2-one	3-Methyloxindole,3-Methyl-2-oxindole	Others , Endogenous Metabolite
	3-Methylindolin-2-one (3-Methyloxindole) is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions with glyoxal derivatives and more.		Others , Endogenous Metabolite
T19717	Cyclo-L-Trp-L-Trp		Antifungal
	Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.		Antifungal
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T28543	RK-9123016	RK9123016,RK 9123016	Sirtuin
	RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer ce...		Sirtuin
T16409	OSMI-1		Others , Acyltransferase
	OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.		Others , Acyltransferase
T4353	SR-18292	SR 18292	Autophagy
	SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.		Autophagy