Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 90.00 | |
10 mg | In stock | $ 151.00 | |
25 mg | In stock | $ 303.00 | |
50 mg | In stock | $ 458.00 | |
100 mg | In stock | $ 673.00 | |
500 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
Targets&IC50 | HDAC6:36 nM, HDAC8:120 nM |
In vitro | As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23 μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. [1] |
Molecular Weight | 284.31 |
Formula | C16H16N2O3 |
CAS No. | 1440209-96-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 5.7 mg/mL (20 mM)), Heating is recommended.
DMSO: 28.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRD73954 1440209-96-0 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Inhibitor Ac-Tubulin inhibit α-tubulin acetylation HeLa cells BRD 73954 Histone deacetylases BRD-73954 H3 acetylation inhibitor