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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4327 | Prexasertib dihydrochloride | LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 | Apoptosis , Chk , S6 Kinase |
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. | |||
T4310 | Prexasertib | LY2606368 | Apoptosis , Chk |
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. | |||
T4488 | GSK-25 | GSK25 | ROCK , S6 Kinase , mTOR |
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). | |||
T6877 | LJH685 | Apoptosis , S6 Kinase | |
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM). | |||
T6878 | LJI308 | S6 Kinase | |
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. | |||
T27471 | GSK299115A | GSK 299115A,GSK-299115A | GRK |
GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively. | |||
T14779 | BRD7389 | SGK , FLT , Pim , CDK , S6 Kinase , DAPK | |
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. | |||
T27467 | GSK270822A | GSK 270822A,GSK-270822A | GRK |
GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively. | |||
T6171 | BI-D1870 | S6 Kinase , Autophagy | |
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4). | |||
T9652 | SB-747651A Dihydrochloride | ROCK | |
SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibit... | |||
T6948 | Pluripotin | SC1 | ERK , Raf , S6 Kinase |
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. | |||
T24020 | DTS | Dibenzyl trisulfide | |
DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential. | |||
T30776 | C-Ceritinib TFA salt | Coupleable ceritinib | |
c-Ceritinib TFA salt is a coupleable ceritinib analog with a linker which also binds multiple other kinases, including FAK1, RSK1/2, ERK1/2, CAMKK2 and FER. | |||
T16896 | SL 0101-1 | SL0101 | S6 Kinase |
SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p... | |||
T10275 | AKT-IN-3 | Akt | |
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin... | |||
T38620 | Prexasertib dimesylate | LY2606368 dimesylate | |
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel... | |||
T63152 | Prexasertib Mesylate Hydrate | ||
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second generation cell cycle detection site kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM). Prexasertib Mesylate Hydrate inhi... | |||
T39733 | Hu7691 free base | Akt | |
Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ... | |||
T11960 | MBM-55 | GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase | |
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. | |||
T11961 | MBM-55S | GSK-3 , MAPK , Akt , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase | |
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities. |