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MBM-55S

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Purity:98.73%

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COA HNMR LCMS HPLC

MBM-55S

Catalog No. T11961Cas No. 2083624-07-9

MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.

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Pack Size	Price	Availability
1 mg	$195	In Stock
2 mg	$293	In Stock
5 mg	$449	In Stock
10 mg	$659	In Stock
25 mg	$987	In Stock
50 mg	$1,390	In Stock
100 mg	$1,880	In Stock
500 mg	$3,780	In Stock
1 mL x 10 mM (in DMSO)	$663	In Stock

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Product Introduction

Bioactivity

Description	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
In vitro	MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 and DYRK1a with IC50s of 5.4 and 6.5 nM. MBM-55S inhibits MGC-803, HCT-116, and Bel-7402 the proliferation of cell with IC50s of 0.53, 0.84, and 7.13 μM, respectively. MBM-55S (0.5-1 μM) induces G2/M phase arrest and accumulation of cells with >4N content and causes cell apoptosis in a concentration-dependent manner in HCT-116 cells[1].
In vivo	In female BALB/c nu/nu mice, MBM-55S (20 mg/kg; i.p) exhibits good antitumor activity. In male Sprague Dawley rats, MBM-55S (1.0 mg/kg; i.v.) shows good pharmacokinetic profile with the CL, T1/2, Vss, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 1.72 hours, 2.53 L/kg, 495 ng/h/mL and 507 ng/h/mL, respectively[1].

Chemical Properties

Molecular Weight	734.73
Formula	C36H39FN6O10
Cas No.	2083624-07-9

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (30.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3610 mL	6.8052 mL	13.6104 mL	68.0522 mL
5 mM	0.2722 mL	1.3610 mL	2.7221 mL	13.6104 mL
10 mM	0.1361 mL	0.6805 mL	1.3610 mL	6.8052 mL
20 mM	0.0681 mL	0.3403 mL	0.6805 mL	3.4026 mL

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