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Catalog No. T11961Cas No. 2083624-07-9
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
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Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
2 mg$293In Stock
5 mg$449In Stock
10 mg$659In Stock
25 mg$987In Stock
50 mg$1,390In Stock
100 mg$1,880In Stock
500 mg$3,780In Stock
1 mL x 10 mM (in DMSO)$663In Stock
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Product Introduction

MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
In vitro
MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 and DYRK1a with IC50s of 5.4 and 6.5 nM. MBM-55S inhibits MGC-803, HCT-116, and Bel-7402 the proliferation of cell with IC50s of 0.53, 0.84, and 7.13 μM, respectively. MBM-55S (0.5-1 μM) induces G2/M phase arrest and accumulation of cells with >4N content and causes cell apoptosis in a concentration-dependent manner in HCT-116 cells[1].
In vivo
In female BALB/c nu/nu mice, MBM-55S (20 mg/kg; i.p) exhibits good antitumor activity. In male Sprague Dawley rats, MBM-55S (1.0 mg/kg; i.v.) shows good pharmacokinetic profile with the CL, T1/2, Vss, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 1.72 hours, 2.53 L/kg, 495 ng/h/mL and 507 ng/h/mL, respectively[1].
Chemical Properties
Molecular Weight734.73
Cas No.2083624-07-9
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 22.5 mg/mL (30.62 mM)
Solution Preparation Table
1 mM1.3610 mL6.8052 mL13.6104 mL68.0522 mL
5 mM0.2722 mL1.3610 mL2.7221 mL13.6104 mL
10 mM0.1361 mL0.6805 mL1.3610 mL6.8052 mL
20 mM0.0681 mL0.3403 mL0.6805 mL3.4026 mL


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