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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13769 | TA-316 | Megakaryocytes/platelets inducing agent | Others |
Megakaryocytes/platelets inducing agent being useful in treating diseases involving thrombopenia. Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cel... | |||
T1986L | Atopaxar Hydrobromide | Protease-activated Receptor | |
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T5519 | Bivalirudin | BG-8967,Hirulog-1 | Thrombin |
Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities. | |||
T1986 | Atopaxar | E5555,ER-172594-00 | Protease-activated Receptor |
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T12870 | SCH79797 dihydrochloride | Apoptosis , Others , Protease-activated Receptor | |
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. | |||
T3839 | Cycloolivil | Isoolivil | Free radical scavengers , Others , Platelet aggregation |
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated t... | |||
T7625 | TRAP-6 | PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) | Protease-activated Receptor |
TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1). | |||
T8236 | RHC 80267 | U-57908 | Others , Phospholipase , COX , Acyltransferase , AChR |
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets) | |||
TP1736L | Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) | Others | |
Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits ... | |||
T15338 | Foropafant | SR27417 | Others , Platelet aggregation |
Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets. | |||
T21996 | Zoniporide hydrochloride | CP-597396 hydrochloride | Sodium Channel |
Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of huma... | |||
T6243 | U-73122 | U73122 | Phospholipase , Ferroptosis , Lipoxygenase |
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN. | |||
T72322 | R 59-022 hydrochloride | DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride | 5-HT Receptor , PKC |
R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R... | |||
TP1458L | Arg-Gly-Glu-Ser acetate(93674-97-6 free base) | Others | |
Arg-Gly-Glu-Ser acetate is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets. | |||
T2238 | Cariporide | HOE-642 | Sodium Channel |
Cariporide (HOE-642) (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (... | |||
T17284 | Zardaverine | BY 290,B 84290 | PDE |
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and... | |||
T25253 | Cinnamtannin B-1 | Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358 | Antioxidant , COX |
Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant a... | |||
T13623 | Compound 48/80 trihydrochloride | C48/80 trihydrochloride | Phospholipase |
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and hista... | |||
T0182L | Clopidogrel hydrogen sulfate | (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel | P450 , P2Y Receptor |
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. | |||
T6040 | Aloxistatin | E64d,Loxistatin,E64c ethyl ester | SARS-CoV , Cysteine Protease |
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with... |