Powder: -20°C for 3 years | In solvent: -80°C for 2 years
SCH79797 dihydrochloride is an effective and selective antagonist of Protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 619.00 | |
100 mg | In stock | $ 879.00 |
Description | SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. |
In vitro | SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. In NIH 3T3 cells, SCH79797 dihydrochloride inhibits serum-stimulated activation of p44/p42 mitogen-activated protein kinases (MAPK) at low concentrations and induces apoptosis at higher concentrations[1]. SCH79797 dihydrochloride inhibits high-affinity thrombin receptor-activating peptide ([3H]haTRAP) binding in a competitive manner. SCH79797 dihydrochloride inhibits α-thrombin- and haTRAP-induced aggregation of human platelets. Thrombin produces transient increases in cytosolic free Ca2+ concentration ([Ca2+]i) in hCASMC. SCH79797 dihydrochloride effectively inhibits this increase in [Ca2+]i. SCH79797 dihydrochloride completely inhibits Thrombin- and TK-stimulated [3H]thymidine incorporation [4]. |
In vivo | In male Sprague Dawley rats, SCH79797 dihydrochloride (2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg; i.v.) reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury immediately before or during ischemia[3]. |
Molecular Weight | 444.4 |
Formula | C23H27Cl2N5 |
CAS No. | 1216720-69-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: 10 mg/mL (22.50 mM), Need ultrasonic and warming
DMSO: 20 mg/mL (45.00 mM), Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SCH79797 dihydrochloride 1216720-69-2 Apoptosis GPCR/G Protein Others Protease-activated Receptor infarct SCH-79797 dihydrochloride SCH-79797 SCH79797 Inhibitor inhibit Nonpeptide thrombin wortmannin SCH 79797 antiproliferative platelets Protease Activated Receptor (PAR) pro-apoptotic thrombosis Thrombin receptors PAR1 cardioprotection inhibitor