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SCH79797 dihydrochloride

SCH79797 dihydrochloride
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SCH79797 dihydrochloride

Catalog No. T12870Cas No. 1216720-69-2
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
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Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$128In Stock
10 mg$197In Stock
25 mg$397In Stock
50 mg$619In Stock
100 mg$879In Stock
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Product Introduction

SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
In vitro
SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. In NIH 3T3 cells, SCH79797 dihydrochloride inhibits serum-stimulated activation of p44/p42 mitogen-activated protein kinases (MAPK) at low concentrations and induces apoptosis at higher concentrations[1]. SCH79797 dihydrochloride inhibits high-affinity thrombin receptor-activating peptide ([3H]haTRAP) binding in a competitive manner. SCH79797 dihydrochloride inhibits α-thrombin- and haTRAP-induced aggregation of human platelets. Thrombin produces transient increases in cytosolic free Ca2+ concentration ([Ca2+]i) in hCASMC. SCH79797 dihydrochloride effectively inhibits this increase in [Ca2+]i. SCH79797 dihydrochloride completely inhibits Thrombin- and TK-stimulated [3H]thymidine incorporation [4].
In vivo
In male Sprague Dawley rats, SCH79797 dihydrochloride (2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg; i.v.) reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury immediately before or during ischemia[3].
Chemical Properties
Molecular Weight444.4
Cas No.1216720-69-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 10 mg/mL (22.50 mM)
DMSO: 20 mg/mL (45.00 mM)
Solution Preparation Table
1 mM2.2502 mL11.2511 mL22.5023 mL112.5113 mL
5 mM0.4500 mL2.2502 mL4.5005 mL22.5023 mL
10 mM0.2250 mL1.1251 mL2.2502 mL11.2511 mL
20 mM0.1125 mL0.5626 mL1.1251 mL5.6256 mL
50 mM0.0450 mL0.2250 mL0.4500 mL2.2502 mL
100 mM0.0225 mL0.1125 mL0.2250 mL1.1251 mL


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