puma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1724L	PUMA BH3 acetate	PUMA BH3 acetate(PUMA BH3 Free base)	BCL
	PUMA BH3 acetate (PUMA BH3 Free base) is a p53 positive regulator of apoptosis (PUMA) BH3 domain polypeptide that acts as a direct activator of Bak with a Kd of 26 nM.		BCL
TP1724	PUMA BH3
	PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.This is a PUMA BH3 domain peptide. PUMA proteins bind Bcl-2, localize to the mitochond...
TP1712	PUMA BH3 (TFA)
	PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.
T75980	PUMA BH3 TFA
	PUMA BH3 (TFA), a peptide from the BH3 domain of the p53 upregulated modulator of apoptosis (PUMA), directly activates Bak with a dissociation constant (Kd) of 26 nM [1].
T83751	PUMA BH3 (human) TFA
	PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) ...
TQ0108	MK-6892		GPR
	MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).		GPR
T12095	Monomethyl fumarate		GPR , Drug Metabolite
	Monomethyl fumarate is a potent agonist of GPR109A .		GPR , Drug Metabolite
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T15432	GSK256073		GPR , Others
	GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inh...		GPR , Others
T19700	IBC 293	IBC293,IBC-293	GPR
	IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes.		GPR
T0794	Mepenzolate Bromide	Colibantil,Cantil,Cantilaque	AChR
	Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.		AChR
T71691	Pumafentrine	BY 343	PDE
	Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.		PDE
T16682	Pumaprazole	BY-841	Proton pump
	Pumaprazole (BY-841) is an antagonist of a reversible proton pump.		Proton pump
T69218	PUMAi HCl
	PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol	BCL , NF-κB , STAT
	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.		BCL , NF-κB , STAT
T16030	Mcl1-IN-8		Others
	Mcl1-IN-8 is an Mcl-1-PUMA interface inhibitor (Ki: 0.3 μM). In cancer cells, Mcl1-IN-8 shows dual activity on reducing PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis.		Others
TMA1743	Ergosterol peroxide		ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
T73000	SIRT2-IN-11
	SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2, demonstrating an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner and activates the expression of CDKN1A, PUMA, and NOXA, wh...
T70008	Bomedemstat ditosylate
	Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro...