Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS-7423 is a small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR (IC50 = 34.9 nM), it also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 175.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 556.00 | |
25 mg | In stock | $ 896.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,650.00 | |
500 mg | In stock | $ 3,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 426.00 |
Description | DS-7423 is a small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR (IC50 = 34.9 nM), it also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM). |
Targets&IC50 | mTOR:34.9 nM, PI3Kγ:249 nM, PI3Kα:15.6 nM, PI3Kβ:1143 nM, PI3Kδ:262 nM |
In vitro | DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2]. |
Molecular Weight | 520.51 |
Formula | C22H27F3N10O2 |
CAS No. | 1222104-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (124.88 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DS-7423 1222104-37-1 PI3K/Akt/mTOR signaling PI3K mTOR Phosphoinositide 3-kinase Inhibitor DS7423 inhibit PUMA TP53 Mammalian target of Rapamycin OCCC TP53AIP1 DS 7423 inhibitor