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Pumaprazole

Name: Pumaprazole
Brand: TargetMol
SKU: T16682
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16682Cas No. 158364-59-1

Alias BY-841

Pumaprazole (BY-841) is an antagonist of a reversible proton pump.

Pumaprazole

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Purity: 99.91%

Catalog No. T16682Alias BY-841Cas No. 158364-59-1

Pumaprazole (BY-841) is an antagonist of a reversible proton pump.

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$198	In Stock
10 mg	$328	In Stock
25 mg	$668	In Stock
50 mg	$1,070	In Stock
100 mg	$1,730	In Stock
200 mg	$2,330	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Batch Information

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Purity:99.91%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Pumaprazole (BY-841) is an antagonist of a reversible proton pump.
In vivo	Pumaprazole shows identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23), and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compared to ranitidine. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect[1].
Synonyms	BY-841

Chemical Properties

Molecular Weight	338.4
Formula	C₁₉H₂₂N₄O₂
Cas No.	158364-59-1
Smiles	COC(=O)Nc1cccc(C)c1CNc1cccn2c(C)c(C)nc12
Relative Density.	1.21g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/ml (162.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	147.7541 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL	29.5508 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	14.7754 mL
20 mM	0.1478 mL	0.7388 mL	1.4775 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9551 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4775 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc