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Pumaprazole

Catalog No. T16682 CAS 158364-59-1

Synonyms: BY-841

Pumaprazole is an antagonist of a reversible <a href="/target/Proton_pump" style="display: inline; color: #c13a36">Proton pump</a>.

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Pumaprazole, CAS 158364-59-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 347.00
5 mg	In stock	$ 896.00
10 mg	In stock	$ 1,427.00
25 mg	In stock	$ 2,137.00
1 mL * 10 mM (in DMSO)	In stock	$ 997.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Pumaprazole is an antagonist of a reversible proton pump.

In vivo

Pumaprazole shows identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23), and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compared to ranitidine. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect[1].

Synonyms	BY-841
Molecular Weight	338.4
Formula	C19H22N4O2
CAS No.	158364-59-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (162.53 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kromer W, et al. Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles. Pharmacology. 2000 May;60(4):179-87.

Related compound libraries

This product is contained In the following compound libraries：

Related Products

Related compounds with same targets

Vonoprazan Bafilomycin A1 Tenatoprazole Bamaquimast Omeprazole sulfide Vonoprazan Fumarate Pumaprazole 5-Hydroxylansoprazole

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pumaprazole 158364-59-1 Membrane transporter/Ion channel Proton pump inhibit BY-841 Proton Pump BY 841 BY841 Inhibitor inhibitor

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