ppar-α — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2824	Pedunculoside		Others , Fatty Acid Synthase
	Pedunculoside is extracted from Ilex rotunda Thunb.		Others , Fatty Acid Synthase
TN1990	Norathyriol		Akt , DNA/RNA Synthesis , AMPK , PPAR
	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.		Akt , DNA/RNA Synthesis , AMPK , PPAR
T8505	SC-236	Sc 236	Apoptosis , COX , PPAR
	SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).		Apoptosis , COX , PPAR
T15575	Indeglitazar	PPM 204	PPAR
	Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).		PPAR
T4408	Elafibranor	GFT505	PPAR
	Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.		PPAR
T12296	Oleoylethanolamide	N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide	Endogenous Metabolite , PPAR
	Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.		Endogenous Metabolite , PPAR
T8486	GW6471	GW 6471	PPAR
	GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.		PPAR
T21587	Muraglitazar	Pargluva,BMS-298585	PPAR
	Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...		PPAR
T2932	Ginsenoside Rh1	Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
	Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T2985	Gypenoside XLIX		PPAR
	Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition		PPAR
T2S0633	Raspberry ketone	Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone	PPAR
	1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can...		PPAR
T17044	Tesaglitazar		PPAR
	Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...		PPAR
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T10506	PPAR agonist 1		PPAR
	PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.		PPAR
T12278	NXT629		Estrogen/progestogen Receptor
	NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).		Estrogen/progestogen Receptor
T33415	MK 0767	MK0767,MK-0767
	MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia.
TN3219	7,8-Didehydrocimigenol		ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR
	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of V...		ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR
T60432	NAAA-IN-3
	NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola...
TN3655	Cimiside E		ERK , TNF , ROS , Akt , PI3K , PKC , PPAR
	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b...		ERK , TNF , ROS , Akt , PI3K , PKC , PPAR
T79454	Anti-NASH agent 1		PPAR
	Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hy...		PPAR