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GW6471

Catalog No. T8486 CAS 880635-03-0

Synonyms: GW 6471

GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.

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GW6471, CAS 880635-03-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 73.00
10 mg	In stock	$ 107.00
25 mg	In stock	$ 227.00
50 mg	In stock	$ 449.00
100 mg	In stock	$ 656.00
500 mg	In stock	$ 1,360.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Purity: 99.88%

Purity: 98.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
In vitro	A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4;?this data was confirmed as specific to PPARα antagonism by siRNA methods.

Synonyms	GW 6471
Molecular Weight	619.67
Formula	C35H36F3N3O4
CAS No.	880635-03-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (193.65 mM), Sonification is recommended.

References and Literature

1. Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115. 2. Xu HE, et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7. 3. Abu Aboud O, et al. PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth. Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C890-8.

Citations

1. Wang R, Zhao J, Jin J, et al. WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC. Lipids in Health and Disease. 2022, 21(1): 1-18.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Glycometabolism Compound Library Anti-Hypertension Compound Library Covalent Inhibitor Library Bioactive Compound Library Lipid Metabolism Compound Library Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max

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Keywords

GW6471 880635-03-0 DNA Damage/DNA Repair Metabolism PPAR Peroxisome proliferator-activated receptors Inhibitor inhibit GW-6471 GW 6471 inhibitor

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