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Oleoylethanolamide

Catalog No. T12296 CAS 111-58-0

Synonyms: N-Oleoylethanolamide, Oleamide MEA, Oleic acid monoethanolamide

Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.

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Oleoylethanolamide, CAS 111-58-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 555.00
200 mg	In stock	$ 772.00
500 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.
In vitro	In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
In vivo	Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.

Synonyms	N-Oleoylethanolamide, Oleamide MEA, Oleic acid monoethanolamide
Molecular Weight	325.53
Formula	C20H39NO2
CAS No.	111-58-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 19.83 mg/mL (60.92 mM), Sonification is recommended.

References and Literature

1. Chen L, et al. Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells. Oncotarget. 2015 Dec 15;6(40):42530-40

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Human Endogenous Metabolite Library Gut Microbial Metabolite Library Anti-Obesity Compound Library Clinical Compound Library Lipid Metabolism Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oleoylethanolamide 111-58-0 DNA Damage/DNA Repair Metabolism Endogenous Metabolite PPAR N-Oleoylethanolamide Inhibitor inhibit Oleamide MEA Peroxisome proliferator-activated receptors Oleic acid monoethanolamide inhibitor

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