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Cat No. | Product Name | Synonyms | Targets |
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T8505 | SC-236 | Sc 236 | Apoptosis , COX , PPAR |
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). | |||
T15575 | Indeglitazar | PPM 204 | PPAR |
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). | |||
T4408 | Elafibranor | GFT505 | PPAR |
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. | |||
T8486 | GW6471 | GW 6471 | PPAR |
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR. | |||
T21587 | Muraglitazar | Pargluva,BMS-298585 | PPAR |
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r... | |||
T17044 | Tesaglitazar | PPAR | |
Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0... | |||
T1415 | Gemfibrozil | CI-719,Jezil,Decrelip,Lopid | P450 , Adrenergic Receptor , PPAR |
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi... | |||
T10506 | PPAR agonist 1 | PPAR | |
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol. | |||
T12278 | NXT629 | Estrogen/progestogen Receptor | |
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM). | |||
T33415 | MK 0767 | MK0767,MK-0767 | |
MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia. | |||
T60432 | NAAA-IN-3 | ||
NAAA-IN-3 (Compound 17a) is a potent and selective NAAA inhibitor with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola... | |||
T79454 | Anti-NASH agent 1 | PPAR | |
Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hy... | |||
T35813 | CAY10592 | ||
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |
Cat No. | Product Name | Synonyms | Targets |
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T2824 | Pedunculoside | Others , Fatty Acid Synthase | |
Pedunculoside is extracted from Ilex rotunda Thunb. | |||
TN1990 | Norathyriol | Akt , DNA/RNA Synthesis , AMPK , PPAR | |
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. | |||
T12296 | Oleoylethanolamide | N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide | Endogenous Metabolite , PPAR |
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α. | |||
T2932 | Ginsenoside Rh1 | Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 | IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin |
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect. | |||
T2985 | Gypenoside XLIX | PPAR | |
Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition | |||
T2S0633 | Raspberry ketone | Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone | PPAR |
1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can... | |||
TN3219 | 7,8-Didehydrocimigenol | ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR | |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of V... | |||
TN3655 | Cimiside E | ERK , TNF , ROS , Akt , PI3K , PKC , PPAR | |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b... |
Cat No. | Product Name | Species | Expression System |
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TMPY-06837 | PPAR alpha/PPARA Protein, Mouse, Recombinant (His) | Mouse | E. coli |
PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204. | |||
TMPY-06830 | PPAR alpha/PPARA Protein, Human, Recombinant (His) | Human | E. coli |
PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869. |