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Search Result

Search Results for " pli "

43

Compounds

3

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T34089 PLI14 PLI-14,PLI 14
PLI14 is a bioactive chemical.
T30098 Aplindore Fumarate Aplindore,DAB-452 Fumarate,DAB-452 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-H...
T40108 Inaxaplin VX-147 Others
Inaxaplin is an apolipoprotein L1 ( APOL1 ) function inhibitor. Inaxaplin can be used for the research of kidney disease.
T9151 Teplinovivint Wnt/beta-catenin
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
T76763 Teplizumab PRV-031,MGA-031 Others
Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.
T77170 Siplizumab MEDI-507 Others
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody targeting CD2. Siplizumab selectively depletes effector memory T cells and promotes relative expansion of alloreactive regulatory T cells in vitro. Siplizumab...
T2511 Plinabulin NPI-2358 Microtubule Associated
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...
T76870 Narsoplimab OMS 721 SARS-CoV
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway ac...
T6678 Splitomicin 1-Naphthalenepropanoic Acid Sirtuin , HDAC
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T77695 Muvalaplin LY3473329 Others
Muvalaplin (LY3473329) is an orally active lipoprotein (a) Lp(a) reagent that inhibits Lp(a) formation by blocking apo(a)-apo B100 interactions.
T28859 ß-Thujaplicinol
ß-Thujaplicinol inhibits the replication of herpes simplex viruses 1 and 2.
T34956 Triplin Others
Triplin is a chelator of copper ion. Triplin affects the transport of copper ions from ATX1 to RAN1.
T11217 Eplivanserin SR-46349 5-HT Receptor
Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.
T76750 Cemiplimab REGN-2810,SAR-439684 Others
Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance...
T74885 RNA splicing modulator 2
RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .
T126497 Plipastatin A2
Plipastatin A2 is a useful organic compound for research related to life sciences. The catalog number is T126497 and the CAS number is 103955-72-2.
T38554 Eteplirsen AVI 4658
Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide utilized in research for Duchenne muscular dystrophy.
TP2355 Tiplimotide NBI5788,NBI-5788,NBI 5788
Tiplimotide is an altered peptide ligand (APL).
T64028 Iruplinalkib
Iruplinalkib is a selective, potent, orally active inhibitor of ALK and ROS1 tyrosine kinases. In advanced NSCLC with ALK or ROS1 rearrangements, Iruplinalkib has a good safety profile and has demonstrated anti-tumour po...
T126496 Plipastatin B2
Plipastatin B2 is a useful organic compound for research related to life sciences. The catalog number is T126496 and the CAS number is 103955-74-4.
T126034 4,15-Isoatriplicolide methylacrylate
4,15-Isoatriplicolide methylacrylate is a useful organic compound for research related to life sciences and the catalog number is T126034.
T82763 CD33 splicing modulator 1 hydrochloride
CD33 Splicing Modulator 1 Hydrochloride (Compound 1) is a myeloid lineage cell surface receptor CD33/Siglec 3 modulator involved in regulating microglia activity. This compound promotes exon 2 skipping in cellular mRNA p...
T62612 CD33 splicing modulator 1
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of n...
T10504 Implitapide Racemate Others
Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T70072 Aplindore
Aplindore is a dopamine receptor agonist used in the therapeutic treatment of Parkinson's Disease.
T27277 Eplivanserin hemifumarate Eplivanserin,SR46349,Eplivanserin fumarate,SR-46349 Fumarate,SR-46349,SR 46349
Eplivanserin is an inverse agonist of 5-HT2A.
T24817 Otaplimastat J3.046.690J,SP8203,SP-8203,SP 8203
SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.
T38731 Intoplicine dimesylate RP 60475 dimesylate
Intoplicine (RP 60475) dimesylate is a DNA topoisomerase I and II inhibitor belonging to the 7H-benzo[e]pyrido[4,3-b]indole series. It exhibits a strong affinity for DNA (K A = 2 x 10^5 /M), resulting in increased linear...
T74886 RNA splicing modulator 3
RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].
T77067 Livmoniplimab
Livmoniplimab (ABBV-151; ARGX-115), a potent humanized monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, inhibits LRRC32-mediated activation of latent TGFβ1. This compound shows promise for cancer research [1].
T74884 RNA splicing modulator 1
RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].
T76825 Ruplizumab
Ruplizumab (BG 9588), a humanized monoclonal IgG1κ antibody targeting CD40L (TNF Receptor), holds promise for research in systemic lupus erythematosus disease [1].
T126033 Isoatriplicolide tiglate
Isoatriplicolide tiglate is a useful organic compound for research related to life sciences and the catalog number is T126033.
T81042 Taplitumomab paptox
Taplitumomab paptox is an anti-CD19 monoclonal antibody utilized in cancer research.
T69308 Spliceostatin A Apoptosis
Spliceostatin A is an anticancer agent and splicing inhibitor that inhibits the splicing mechanism of the spliceosome and inhibits mitotic clonal expansion and adipogenesis.Spliceostatin A induces cell cycle arrest in th...
T15586 Intoplicine Topoisomerase
Intoplicine is an inhibitor of DNA topoisomerase I and II.
T15570 Implitapide AEGR 427 CETP
Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T19995 C.I. Azoic Coupling Component 5 NSC 37212,NSC37212,Cibanaphthol AG,Diacetylacetotolidide,Daito Grounder G,NSC-37212
C.I. Azoic Coupling Component 5 is an indicator of fluorescent.
T78323 Letaplimab IBI-188
Letaplimab (IBI-188), a humanized IgG4 monoclonal antibody targeting CD47—which is often overexpressed in cancer cells and acts as a ligand for SIRPα—has been shown to promote phagocytosis of tumor cells [1].
T11216 Eplivanserin (mixture) Eplivanserin mixture,SR-46349 (mixture) 5-HT Receptor
Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist,
T125512 Ceplignan
Ceplignan is a useful organic compound for research related to life sciences and the catalog number is T125512.
T82984 Aplithianines A PKA
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by competitively interacting with the ATP pocket [1].
TP2467 Plipastatin B 1
Plipastatin B 1 is a lipopeptide.

Compounds

PLI14
T34089
Synonym: PLI-14,PLI 14
Target:
Aplindore Fumarate
T30098
Synonym: Aplindore,DAB-452 Fumarate,DAB-452
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Inaxaplin
T40108
Synonym: VX-147
Target: Others
Teplinovivint
T9151
Synonym:
Target: Wnt/beta-catenin
Teplizumab
T76763
Synonym: PRV-031,MGA-031
Target: Others
Siplizumab
T77170
Synonym: MEDI-507
Target: Others
Plinabulin
T2511
Synonym: NPI-2358
Target: Microtubule Associated
Narsoplimab
T76870
Synonym: OMS 721
Target: SARS-CoV
Splitomicin
T6678
Synonym: 1-Naphthalenepropanoic Acid
Target: Sirtuin, HDAC
Muvalaplin
T77695
Synonym: LY3473329
Target: Others
ß-Thujaplicinol
T28859
Synonym:
Target:
Triplin
T34956
Synonym:
Target: Others
Eplivanserin
T11217
Synonym: SR-46349
Target: 5-HT Receptor
Cemiplimab
T76750
Synonym: REGN-2810,SAR-439684
Target: Others
RNA splicing modulator 2
T74885
Synonym:
Target:
Plipastatin A2
T126497
Synonym:
Target:
Eteplirsen
T38554
Synonym: AVI 4658
Target:
Tiplimotide
TP2355
Synonym: NBI5788,NBI-5788,NBI 5788
Target:
Iruplinalkib
T64028
Synonym:
Target:
Plipastatin B2
T126496
Synonym:
Target:
4,15-Isoatriplicolide methylacrylate
T126034
Synonym:
Target:
CD33 splicing modulator 1 hydrochloride
T82763
Synonym:
Target:
CD33 splicing modulator 1
T62612
Synonym:
Target:
Implitapide Racemate
T10504
Synonym:
Target: Others
Aplindore
T70072
Synonym:
Target:
Eplivanserin hemifumarate
T27277
Synonym: Eplivanserin,SR46349,Eplivanserin fumarate,SR-46349 Fumarate,SR-46349,SR 46349
Target:
Otaplimastat
T24817
Synonym: J3.046.690J,SP8203,SP-8203,SP 8203
Target:
Intoplicine dimesylate
T38731
Synonym: RP 60475 dimesylate
Target:
RNA splicing modulator 3
T74886
Synonym:
Target:
Livmoniplimab
T77067
Synonym:
Target:
RNA splicing modulator 1
T74884
Synonym:
Target:
Ruplizumab
T76825
Synonym:
Target:
Isoatriplicolide tiglate
T126033
Synonym:
Target:
Taplitumomab paptox
T81042
Synonym:
Target:
Spliceostatin A
T69308
Synonym:
Target: Apoptosis
Intoplicine
T15586
Synonym:
Target: Topoisomerase
Implitapide
T15570
Synonym: AEGR 427
Target: CETP
C.I. Azoic Coupling Component 5
T19995
Synonym: NSC 37212,NSC37212,Cibanaphthol AG,Diacetylacetotolidide,Daito Grounder G,NSC-37212
Target:
Letaplimab
T78323
Synonym: IBI-188
Target:
Eplivanserin (mixture)
T11216
Synonym: Eplivanserin mixture,SR-46349 (mixture)
Target: 5-HT Receptor
Ceplignan
T125512
Synonym:
Target:
Aplithianines A
T82984
Synonym:
Target: PKA
Plipastatin B 1
TP2467
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T9715 Aplidine SARS-CoV , DNA/RNA Synthesis
Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).
T83864 Plipastatin A1 SNA-60-367-3,Fengycin IX
Plipastatin A1, a lipopeptide isolated from B. cereus, demonstrates enzyme inhibitory and immunosuppressant properties. It effectively inhibits enzymes phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D ...
T36303 Psammaplin A
Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobi...

Natural Products

Aplidine
T9715
Synonym:
Target: SARS-CoV, DNA/RNA Synthesis
Plipastatin A1
T83864
Synonym: SNA-60-367-3,Fengycin IX
Target:
Psammaplin A
T36303
Synonym:
Target:

Recombinant Proteins

Species：
Mouse (2)
Cynomolgus (1)
Human (1)
IBV (1)
Streptomyces plicatus (1)
Expression System：
HEK293 Cells (3)
P. pastoris (Yeast) (2)
Baculovirus Insect Cells (1)
Tag：
C-6xHis (3)
C-His (3)
Cat No. Product Name Species Expression System
TMPY-01026 Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q5ND36.
TMPY-01398 Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His) Human HEK293 Cells
Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.2 kDa and the accession number is P08697-1.
TMPK-00540 Serpin F2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Large-pool solvent/detergent (SD) plasma for transfusion exhibits reduced alpha 2-antiplasmin (alpha2-AP; SERPINF2) functional activity. The reason for the loss of alpha2-AP has not been described and could be due to the...
TMPH-00147 IBV (strain KB8523) Replicase polyprotein 1ab (His) IBV Baculovirus Insect Cells
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as...
TMPH-02819 Otoraplin Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Otoraplin Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 14.0 kDa and the accession number is Q9JIE3.
TMPH-00514 Endo H Protein, Streptomyces plicatus, Recombinant (His) Streptomyces plicatus P. pastoris (Yeast)
Cleaves asparagine-linked oligomannose and hybrid, but not complex, oligosaccharides from glycoproteins.
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