Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 57.00 | |
25 mg | In stock | $ 117.00 | |
50 mg | In stock | $ 182.00 | |
100 mg | In stock | $ 343.00 | |
200 mg | In stock | $ 497.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
Targets&IC50 | Sir2p:60 μM |
In vitro | Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. [1] Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release. [2] |
In vivo | In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation. [3] |
Synonyms | 1-Naphthalenepropanoic Acid |
Molecular Weight | 198.22 |
Formula | C13H10O2 |
CAS No. | 5690-03-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.8 mg/mL (100 mM)
Ethanol: 19.8 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Splitomicin 5690-03-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin HDAC 1-Naphthalenepropanoic Acid Inhibitor Histone deacetylases Splitomycin inhibit inhibitor