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Splitomicin

Catalog No. T6678   CAS 5690-03-9
Synonyms: 1-Naphthalenepropanoic Acid

Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.

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Splitomicin Chemical Structure
Splitomicin, CAS 5690-03-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 57.00
25 mg In stock $ 117.00
50 mg In stock $ 182.00
100 mg In stock $ 343.00
200 mg In stock $ 497.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.11%
Purity: 98.64%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
Targets&IC50 Sir2p:60 μM
In vitro Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. [1] Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release. [2]
In vivo In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation. [3]
Synonyms 1-Naphthalenepropanoic Acid
Molecular Weight 198.22
Formula C13H10O2
CAS No. 5690-03-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 19.8 mg/mL (100 mM)

Ethanol: 19.8 mg/mL (100 mM)

TargetMolReferences and Literature

1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118. 2. Liu FC, et al. Thromb Res. 2009, 124(2), 199-207. 3. Parker BL, et al. J Biol Chem. 2014, 289(37), 25890-25906.

Related compound libraries

This product is contained In the following compound libraries:
Reprogramming Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library Anti-Cancer Compound Library Anti-Diabetic Compound Library Anti-Aging Compound Library NO PAINS Compound Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library Epigenetics Compound Library

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Keywords

Splitomicin 5690-03-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin HDAC 1-Naphthalenepropanoic Acid Inhibitor Histone deacetylases Splitomycin inhibit inhibitor

 

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