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Catalog No. T15570   CAS 177469-96-4
Synonyms: AEGR 427

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

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Implitapide Chemical Structure
Implitapide, CAS 177469-96-4
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25 mg 10-14 weeks $ 2,570.00
50 mg 10-14 weeks $ 3,380.00
100 mg 10-14 weeks $ 4,600.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
In vitro Implitapide inhibits MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC50=10 nM). Implitapide also inhibits the secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) (IC50: 1.1 nM)[1].
In vivo Administering Implitapide (3.2 mg/kg/d) significantly inhibits lipid-stained lesions in mice on a Western-type diet (WD), reducing lesion area by 83% compared to the WD group (p<0.01) and substantially lowering plasma lipid levels to near or below those on a chow diet (CD) at both 4 and 8 weeks of treatment (p<0.01). Furthermore, this dosage of Implitapide markedly reduces lipid-stained aortic lesions by 83% in apoE knockout (KO) mice. In addition, apoE KO mice fed a WD supplemented with varying doses of Implitapide (1, 5, and 15 mg/kg/d) for 14 weeks exhibit a significant decrease in both plaque area (66, 78, and 93% reduction, respectively) and lipid content within plaques (to 4.3, 2.6, and 0%, respectively, compared with 9.5% in controls)[1].
Synonyms AEGR 427
Molecular Weight 531.69
Formula C35H37N3O2
CAS No. 177469-96-4


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ueshima K, et al. Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull. 2005 Feb;28(2):247-52.

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Implitapide 177469-96-4 Metabolism CETP AEGR427 AEGR 427 AEGR-427 inhibitor inhibit