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Otaplimastat

Catalog No. T24817 CAS 1176758-04-5

Synonyms: J3.046.690J, SP8203, SP-8203, SP 8203

SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Otaplimastat, CAS 1176758-04-5

Pack Size	Availability	Price/USD	Quantity
25 mg	6-8 weeks	$ 1,430.00
50 mg	6-8 weeks	$ 1,860.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.

Synonyms	J3.046.690J, SP8203, SP-8203, SP 8203
Molecular Weight	534.61
Formula	C28H34N6O5
CAS No.	1176758-04-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Han SY, Yoon I, Chin YW, Cho IW, Lee MG, Choi YH. Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily. Xenobiotica. 2012 Oct;42(10):1017-27. doi: 10.3109/00498254.2012.663117. Epub 2012 May 9. PubMed PMID: 22568632. 2. Noh SJ, Lee JM, Lee KS, Hong HS, Lee CK, Cho IH, Kim HS, Suh YH. SP-8203 shows neuroprotective effects and improves cognitive impairment in ischemic brain injury through NMDA receptor. Pharmacol Biochem Behav. 2011 Nov;100(1):73-80. doi: 10.1016/j.pbb.2011.07.018. Epub 2011 Aug 1. PubMed PMID: 21835192. 3. Noh SJ, Lee SH, Shin KY, Lee CK, Cho IH, Kim HS, Suh YH. SP-8203 reduces oxidative stress via SOD activity and behavioral deficit in cerebral ischemia. Pharmacol Biochem Behav. 2011 Mar;98(1):150-4. doi: 10.1016/j.pbb.2010.12.014. Epub 2010 Dec 21. PubMed PMID: 21172384. 4. Lee JH, Choi YH, Suh JH, Kang HE, Lee TH, Cho IH, Lee MG. Dose-dependent pharmacokinetics of SP-8203 in rats. Biopharm Drug Dispos. 2010 Jul;31(5-6):358-61. doi: 10.1002/bdd.713. PubMed PMID: 20578211.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Otaplimastat 1176758-04-5 J3.046.690J SP8203 SP-8203 SP 8203 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.