nrf2/ho-1-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72827	Nrf2/HO-1-IN-1
	Nrf2/HO-1-IN-1 is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammat...
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T6S0525	Farrerol		ERK , p38 MAPK , Akt
	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3....		ERK , p38 MAPK , Akt
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
T74540	Anti-inflammatory agent 38
	Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for...
T61522	Nrf2/HO-1 activator 2
	Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway t...
T61205	Nrf2/HO-1 activator 1
	Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustratin...
T79930	Sanggenon A	Sanggenone A	NF-κB
	Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it significantly suppresses Lipopolysaccharide (LPS)-induced nitric...		NF-κB
T34811	Terrein	NSC 291308,Terrain,(+)Terrein,NSC291308,NSC-291308
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+...
T62111	Antioxidant agent-5
	Antioxidant agent-5 (compound D-6) is a potent antioxidant. antioxidant agent-5 inhibits oxLDL-induced increases in ROS levels and NF-κB nuclear translocation. antioxidant agent-5 inhibits oxLDL (oxidized LDL)-induced ap...
TN3806	Dehydroglyasperin C		ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv...