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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10526 | β-NF-JQ1 | Others | |
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter... | |||
T39924 | NF-κΒ activator 2 | NF-κB | |
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo... | |||
T3893 | Forsythoside B | TNF , NF-κB | |
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect... | |||
T9105 | NF-κB-IN-1 | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- | IκB/IKK , NF-κB |
NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T6S0781 | Phellodendrine | Phallodendrin | Others , NF-κB , Akt |
1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
T13265 | Urolithin B | ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK | |
Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit... | |||
T8705 | BOT-64 | IκB/IKK | |
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound | |||
T0708 | Oxaprozin | Oxaprozinum,Wy21743 | NF-κB , COX |
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound... | |||
TD0099 | Malachite green oxalate | Apoptosis , Others , IκB/IKK , NF-κB | |
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T0607 | Dihydroartemisinin | β-Dihydroartemisinin,Dihydroqinghaosu,Artenimol,DHA | Apoptosis , NF-κB , Parasite , Autophagy |
Dihydroartemisinin (Artenimol) is a metabolite of artemisinin. | |||
T13981 | β-Naphthoflavone-CH2-Br | β-NF-CH2-Br | Others |
β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1. | |||
T17363 | β-Naphthoflavone-CH2-OH | β-NF-CH2-OH | Others |
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These... | |||
T2279 | Tizoxanide | Desacetyl-nitazoxanide,TIZ | Antiviral , HIV Protease , Antibacterial , Autophagy |
Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). | |||
T2872 | Ginsenoside Re | Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re | Beta Amyloid , NF-κB , Endogenous Metabolite , JNK |
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors. | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T2P2870 | Damascenone | trans-damascenone,Beta-Damascenone | Others , NF-κB , Endogenous Metabolite |
Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes. | |||
T2775 | Baicalin | Baicalein 7-O-β-D-glucuronide | NF-κB , HIV Protease , GABA Receptor , Autophagy |
Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties. | |||
TN1182 | 11-Keto-beta-boswellic acid | 11-Keto-beta-boswellic acid | Leukotriene Receptor , NF-κB , Lipoxygenase |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas... |