Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1].
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Description | β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1]. |
Synonyms | β-NF-CH2-OH |
Molecular Weight | 302.32 |
Formula | C20H14O3 |
CAS No. | T17363 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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β-Naphthoflavone-CH2-OH T17363 Others beta-NF-CH2-OH beta-Naphthoflavone-CH2-OH b-Naphthoflavone-CH2-OH β-Naphthoflavone-CH-2-OH β-NF-CH2-OH b-NF-CH2-OH β Naphthoflavone CH2 OH βNaphthoflavoneCH2OH inhibitor inhibit