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Search Results for " immunosuppressant "

20

Compounds

Cat No. Product Name Synonyms Targets
T79791 Immunosuppressant-1 Apoptosis
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce...
T8527 CPYPP Others
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY...
T8546 BD750 JAK , STAT
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)
T7527 Frentizole Beta Amyloid
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
T4507 Chlorphenesin Adermykon,Chlorophenesin,Gecophen Antibacterial , Antifungal , Histamine Receptor
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
T8003 Methotrexate disodium Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
TCS1554 Trans-Benzylideneacetone Acetocinnamone Phospholipase
trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.
T2884 Cortisone Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone Glucocorticoid Receptor , Endogenous Metabolite
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity.
T6033 Zotarolimus ABT-578,A 179578 mTOR
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
T0034 Cortisone acetate Cortisone 21-acetate,NSC 49420 Glucocorticoid Receptor , Endogenous Metabolite
Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate (NSC-49420) d...
T2481 Ascomycin FK520,Immunomycin,FR-900520 Phosphatase , Others , Antibiotic , Parasite , Antifungal
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
T1188 Mizoribine Bredinin,NSC 289637,HE 69 HCV Protease , SARS-CoV , Tyrosinase
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
T1537 Rapamycin Sirolimus,AY 22989,NSC-2260804 Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T1485 Methotrexate NCI-C04671,WR19039,Amethopterin,CL14377 Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...
T31645 EO-1606 EO 1606,EO1606
Eo-1606 is a potential immunosuppressant for the treatment of dermatitis.
T19971 Cyclosporin C CsC,Cs-C,Cyclosporin-C Antiviral , Antifungal
Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi. Cyclosporin C has antifungal, antiviral, and immunosuppressant properties.
T17235 Voclosporin ISAtx-247 Phosphatase
Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephritis.
T16045 Methotrexate metabolite DAMPA Antifolate , Drug Metabolite
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
T2648 Pimecrolimus SDZ-ASM 981,ASM 981 Others
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...
T0245 RS 61443 RS61443,Mycophenolate mofetil,TM-MMF Dehydrogenase
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)

Compounds

Immunosuppressant-1
T79791
Synonym:
Target: Apoptosis
CPYPP
T8527
Synonym:
Target: Others
BD750
T8546
Synonym:
Target: JAK, STAT
Frentizole
T7527
Synonym:
Target: Beta Amyloid
Chlorphenesin
T4507
Synonym: Adermykon,Chlorophenesin,Gecophen
Target: Antibacterial, Antifungal, Histamine Receptor
Methotrexate disodium
T8003
Synonym:
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
trans-Benzylideneacetone
TCS1554
Synonym: Acetocinnamone
Target: Phospholipase
Cortisone
T2884
Synonym: Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone
Target: Glucocorticoid Receptor, Endogenous Metabolite
Zotarolimus
T6033
Synonym: ABT-578,A 179578
Target: mTOR
Cortisone acetate
T0034
Synonym: Cortisone 21-acetate,NSC 49420
Target: Glucocorticoid Receptor, Endogenous Metabolite
Ascomycin
T2481
Synonym: FK520,Immunomycin,FR-900520
Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal
Mizoribine
T1188
Synonym: Bredinin,NSC 289637,HE 69
Target: HCV Protease, SARS-CoV, Tyrosinase
Rapamycin
T1537
Synonym: Sirolimus,AY 22989,NSC-2260804
Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal
Methotrexate
T1485
Synonym: NCI-C04671,WR19039,Amethopterin,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
EO-1606
T31645
Synonym: EO 1606,EO1606
Target:
Cyclosporin C
T19971
Synonym: CsC,Cs-C,Cyclosporin-C
Target: Antiviral, Antifungal
Voclosporin
T17235
Synonym: ISAtx-247
Target: Phosphatase
Methotrexate metabolite
T16045
Synonym: DAMPA
Target: Antifolate, Drug Metabolite
Pimecrolimus
T2648
Synonym: SDZ-ASM 981,ASM 981
Target: Others
RS 61443
T0245
Synonym: RS61443,Mycophenolate mofetil,TM-MMF
Target: Dehydrogenase
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TargetMol