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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T79791 | Immunosuppressant-1 | Apoptosis | |
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce... | |||
T8527 | CPYPP | Others | |
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY... | |||
T8546 | BD750 | JAK , STAT | |
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively) | |||
T7527 | Frentizole | Beta Amyloid | |
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction | |||
T4507 | Chlorphenesin | Adermykon,Chlorophenesin,Gecophen | Antibacterial , Antifungal , Histamine Receptor |
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent. | |||
T8003 | Methotrexate disodium | Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate | |
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor | |||
TCS1554 | Trans-Benzylideneacetone | Acetocinnamone | Phospholipase |
trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations. | |||
T2884 | Cortisone | Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone | Glucocorticoid Receptor , Endogenous Metabolite |
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity. | |||
T6033 | Zotarolimus | ABT-578,A 179578 | mTOR |
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM). | |||
T0034 | Cortisone acetate | Cortisone 21-acetate,NSC 49420 | Glucocorticoid Receptor , Endogenous Metabolite |
Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate (NSC-49420) d... | |||
T2481 | Ascomycin | FK520,Immunomycin,FR-900520 | Phosphatase , Others , Antibiotic , Parasite , Antifungal |
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. | |||
T1188 | Mizoribine | Bredinin,NSC 289637,HE 69 | HCV Protease , SARS-CoV , Tyrosinase |
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. | |||
T1537 | Rapamycin | Sirolimus,AY 22989,NSC-2260804 | Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal |
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy. | |||
T1485 | Methotrexate | NCI-C04671,WR19039,Amethopterin,CL14377 | Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate |
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... | |||
T31645 | EO-1606 | EO 1606,EO1606 | |
Eo-1606 is a potential immunosuppressant for the treatment of dermatitis. | |||
T19971 | Cyclosporin C | CsC,Cs-C,Cyclosporin-C | Antiviral , Antifungal |
Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi. Cyclosporin C has antifungal, antiviral, and immunosuppressant properties. | |||
T17235 | Voclosporin | ISAtx-247 | Phosphatase |
Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephritis. | |||
T16045 | Methotrexate metabolite | DAMPA | Antifolate , Drug Metabolite |
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. | |||
T2648 | Pimecrolimus | SDZ-ASM 981,ASM 981 | Others |
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... | |||
T0245 | RS 61443 | RS61443,Mycophenolate mofetil,TM-MMF | Dehydrogenase |
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) |