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BD750

Catalog No. T8546 CAS 892686-59-8

BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)

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BD750, CAS 892686-59-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 409.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)
In vitro	Following BD750 treatment, LPS-induced maturation of DC, allogeneic T cell proliferation, Th1 and Th17 cell functional differentiation, the STAT5 and AKT activation were determined.?The effect of tolDC loaded with antigen peptide on the development and severity of EAE and their splenic Th1 and Th17 cell responses were determined.?In comparison with LPS-induced mature DC (mDC), BD750 treatment induced tolDC with lower expression levels of costimulatory molecules and pro-inflammatory cytokines and lower levels of STAT5 phosphorylation.?TolDC inhibited allogeneic T cell proliferation and reduced Th1 and Th17 responses[1].
In vivo	Adoptive transfer of tolDC loaded with MOG35-55 inhibited the development and severity of EAE in mice, accompanied by reduced numbers of inflammatory infiltrates and decreased levels of demyelination in the spinal cord tissues of mice.?In addition, treatment with tolDC loaded with antigen peptide also significantly reduced the frequency of splenic Th1 and Th17 cells in EAE mice.?The effects of tolDC were similar to that of the JAK/STAT inhibitor, CP690550-treated DC[1].
Animal Research	Female C57BL/6 mice (10 wks old, 19-21 g).Dosage with 20 μM, and administration:IV, treated DC on d 7, 11 and 15 post the first PTX injection (dpi 7, 11 and 15)[1].

Molecular Weight	271.34
Formula	C14H13N3OS
CAS No.	892686-59-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (101.35 mM)

References and Literature

1. Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214. 2. Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43.

Citations

1. Zhang Y, Zhao L, Wu A, et al.Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes.Microbes and Infection.2023: 105232.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Angiogenesis related Compound Library Bioactive Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Reprogramming Compound Library Immunology/Inflammation Compound Library Anti-Cancer Metabolism Compound Library

Related Products

Related compounds with same targets

Momelotinib sulfate Fedratinib JAK3-IN-7 WDR5-IN-6 Ilginatinib maleate Mollugin TG-89 SB1317

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Keywords

BD750 892686-59-8 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT Immunosuppressant BD-750 BD 750 cell Janus kinase inhibit Inhibitor inhibitor

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