Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 396.00 | |
100 mg | In stock | $ 592.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9 |
Targets&IC50 | GEF activity of DOCK2DHR-2 for Rac1:22.8 µM |
In vitro | CPYPP as a small-molecule inhibitor of DOCK2.?CPYPP bound to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.?When lymphocytes were treated with CPYPP, both chemokine receptor- and antigen receptor-mediated Rac activation were blocked, resulting in marked reduction of chemotactic response and T cell activation.?These results provide a rational of and a chemical scaffold for development of the DOCK2-targeting immunosuppressant[1]. |
Molecular Weight | 324.76 |
Formula | C18H13ClN2O2 |
CAS No. | 310460-39-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 23 mg/mL (70.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CPYPP 310460-39-0 Others DOCK2 Inhibitor GEF Rac1 DOCK180 lymphocytes autoimmune DOCK2-Rac1 inhibit DOCK5 immunosuppressant migration inhibitor