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Mizoribine

Catalog No. T1188   CAS 50924-49-7
Synonyms: Bredinin, NSC 289637, HE 69

Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

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Mizoribine Chemical Structure
Mizoribine, CAS 50924-49-7
Pack Size Availability Price/USD Quantity
10 mg In stock $ 45.00
25 mg In stock $ 61.00
50 mg In stock $ 97.00
100 mg In stock $ 166.00
200 mg In stock $ 216.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.98%
Purity: 98.38%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Targets&IC50 immunosuppressive:100 μM
In vitro Mizoribine selectively inhibits guanine ribonucleotide synthesis in purified T-cells, while the mechanism of 6-thioguanine (6MP) appears to rely more on the depletion of adenine ribonucleotides. In a dose-dependent manner, Mizoribine at 1-50 mg/mL suppresses T-cell proliferation induced by all tested stimuli by 10-100%. This suppression is reversible with the addition of guanosine to replenish the guanine nucleotide pool when 50 mM is incorporated. Furthermore, Mizoribine impedes HCV RNA replication with an IC50 of 100 μM and causes a reduction in intracellular GTP levels, with GTP supplementation reversing its antiproliferative effect.
In vivo Administration of 5 or 10 mg/kg Mizoribine resulted in increased expression of MCP-1, OPN, and TGF-β1 mRNA in untreated OLETF rats. Simultaneously, this dose of Mizoribine inhibited urinary albumin excretion and attenuated the progression of glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in the rat kidneys.
Synonyms Bredinin, NSC 289637, HE 69
Molecular Weight 259.22
Formula C9H13N3O6
CAS No. 50924-49-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35 mg/mL(135 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 47 mg/mL (181.3 mM)

TargetMolReferences and Literature

1. Turka LA, et al. J Clin Invest, 1991, 87(3), 940-948. 2. Dayton JS, et al. Mol Pharmacol, 1992, 41(4), 671-676. 3. Naka K, et al. Biochem Biophys Res Commun, 2005, 330(3), 871-879. 4. Kikuchi Y, et al. Nephrol Dial Transplant, 2005, 20(8), 1573-1581.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Human Metabolite Library Drug Repurposing Compound Library Clinical Compound Library Approved Drug Library Nucleotide Compound Library Natural Product Library RO5 Drug-like Natural Product Library Anti-Tumor Natural Product Library Anti-Aging Compound Library

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Keywords

Mizoribine 50924-49-7 Microbiology/Virology Proteases/Proteasome SARS-CoV HCV Protease Tyrosinase Immunosuppressant Bredinin IMPDH NSC289637 NSC 289637 nucleoside Hepatitis C virus HE 69 HE-69 HCV SARS coronavirus NSC-289637 Inhibitor inhibit HE69 inhibitor

 

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