igf-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1122L	IGF-I 30-41 acetate(82177-09-1 free base)	Insulin-like Growth Factor I (30-41) acetate	Others
	IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).		Others
T9625	Sandalore		Apoptosis
	Sandalore prolongs human hair growth by decreasing apoptosis and increasing the production of the anagen-prolonging growth factor IGF-1 in the outer root sheath. Sandalore is a selective agonist of olfactory receptor OR2...		Apoptosis
T9692	Paltusotine		Somatostatin
	Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients		Somatostatin
TP1121	IGF-I (30-41) TFA(82177-09-1,FREE)	Insulin-like Growth Factor I (30-41) (TFA)
	IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R
T6419	BMS-536924	HY-10262,BMS 536924,CS-0117	Apoptosis , FAK , MEK , IGF-1R , Src
	BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.		Apoptosis , FAK , MEK , IGF-1R , Src
T2693	AG1024	Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis , IGF-1R
	AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).		Apoptosis , IGF-1R
T2085	PQ401	IGF-1R Inhibitor II	Apoptosis , IGF-1R
	PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).		Apoptosis , IGF-1R
T4324	PQ401 hydrochloride (196868-63-0(free base))		IGF-1R
	PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.		IGF-1R
T67707	Tyrphostin AG 538	AG 538	IGF-1R
	Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.		IGF-1R
T6943	Picropodophyllin	AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP	Apoptosis , IGF-1R
	Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with...		Apoptosis , IGF-1R
T76727	Teprotumumab	R 1507,HZN 001	TSH Receptor , IGF-1R
	Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...		TSH Receptor , IGF-1R
T11593	I-OMe-Tyrphostin AG 538	I-OMe-AG 538	IGF-1R , PI3K
	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-d...		IGF-1R , PI3K
T6017	Linsitinib	OSI-906	IGF-1R
	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...		IGF-1R
T68405	KW-2450 free base		IGF-1R
	KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and inhibits IGF-1-induced signaling in a mouse HT-29/GFP colo...		IGF-1R
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T2349	BMS-754807		Trk receptor , c-Met/HGFR , IGF-1R
	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity.		Trk receptor , c-Met/HGFR , IGF-1R
T40646	Lipoteichoic acid		Complement System
	Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.		Complement System