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Cat No. | Product Name | Synonyms | Targets |
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T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T21588 | Olomoucine | ERK , CDK | |
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an... | |||
T2028 | NG 52 | NG52,NG-52,Compound 52 | CDK |
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase. | |||
T7167 | Purvalanol B | NG 95 | CDK , Parasite |
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) | |||
T9156 | CDC25B-IN-2 | Phosphatase , mTOR | |
BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression. | |||
T10723 | CDC25B-IN-1 | ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate | Phosphatase |
CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation. | |||
T76458 | P34cdc2 Kinase Fragment | ||
P34cdc2 Kinase Fragment plays a crucial role in yeast mitosis by ensuring the completion of DNA replication and regulates microtubule polymerization in Xenopus oocytes meiosis by phosphorylating mitogen-activated protein... | |||
T82762 | Cdc25A (80-93) (human) | ||
Cdc25A (80-93) (human) is a polypeptide implicated in the regulation of cell proliferation and tumorigenesis through modulation of cyclin D1 expression and facilitation of the G1/S phase transition. This compound has app... | |||
T2095 | Seliciclib | Roscovitine,R-roscovitine,CYC202 | CDK |
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). | |||
T3074 | CHIR 98024 | CHIR98014 | GSK-3 , S6 Kinase |
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. | |||
T15438 | GSK3186899 | 3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide,DDD-853651 | Parasite |
GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani. | |||
T2670 | ML167 | NCGC00188654,CID44968231 | DYRK , CDK |
ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor. | |||
T2059 | Purvalanol A | NG-60 | Apoptosis , CDK , Autophagy |
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. | |||
T1901 | (E/Z)-TG003 | TG003 | BCL , CDK |
(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor. | |||
T6350 | CHIR-124 | CHIR124,CHIR 124 | Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src |
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. | |||
T9864 | Debio-0123 | WEE1-IN-5 | Wee1 |
Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and prema... | |||
T2310L | CHIR-99021 HCl | CT99021 HCl,Laduviglusib HCl | GSK-3 |
CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit... | |||
T2608 | CHIR-98014 | CHIR 98014,CT98014,CHIR98014 | FGFR , GSK-3 , Src , S6 Kinase |
CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo. | |||
T16848 | SB-218078 | Chk , PKC | |
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50... | |||
T15657 | KH-CB19 | Others | |
KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). | |||
T22657 | Laduviglusib trihydrochloride | CT99021 trihydrochloride,CHIR 99021 trihydrochloride,CHIR 99021 trihydrochloride (252917-06-9 free base) | GSK-3 , Wnt/beta-catenin |
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-... | |||
T24402 | Leucettine L41 | LeucettineL41,Leucettine-L41 | |
Leucettine L41 is an effective dual cdc2-like kinase and DYRKs inhibitor. | |||
T68453 | HY-52 | ||
HY-52 is a selective inhibitor of CDC2 kinase. | |||
T10836 | CLK1-IN-1 | CDK | |
CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM). | |||
T62049 | CTX-712 | ||
CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth. | |||
T70527 | DAT-230 | ||
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -tr... | |||
T21950 | K 00546 | ||
K00546, a potent inhibitor of both cyclin-dependent kinase (CDK1 and CDK2) and CDC2-like kinase (CLK1 and CLK3), demonstrates high specificity with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respecti... | |||
T28092 | MPT0B206 | ||
MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1... | |||
T69091 | CBP501 | ||
CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-spec... | |||
T69316 | DA 3003-2 | NSC663285 | |
DA 3003-2, a selectively potent Cdc25 inhibitor, exhibits antiproliferative activity and holds potential for prostate cancer research. It induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr ... | |||
T60737 | LG308 | ||
LG308 shows antimicrotubule activity which is a novel synthetic compound. LG308 induces apoptosis, cell death, and significantly suppresses tumor growth that has the potential for the prostate cancer research. LG308 indu... | |||
TP2192 | Cdk2/Cyclin Inhibitory Peptide I | Others | |
Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar... | |||
T71217 | MPT0B214 | ||
MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activ... | |||
T69200 | CGP74514A | ||
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t... | |||
T62484 | Aurora Kinases-IN-2 | ||
Aurora Kinases-IN-2 (compound 12Aj) is a potent inhibitor of Aurora kinases, acting on Aurora A (IC50: 90 nM) and Aurora B (IC50: 152 nM). Aurora Kinases-IN-2 can be used in cancer research. | |||
T36689 | KuWal151 | ||
Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T25192 | Butyrolactone I | Olomoucin | CDK |
Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines. | |||
T5S1467 | Cucurbitacin E | CDK , Autophagy | |
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot... | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
TN5639 | Rocaglaol | Ferrugin,Aglaiastatin A | |
Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04775 | CDK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells |
CDK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 61.9 kDa and the accession number is P11440. | |||
TMPY-04549 | CDK1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
CDK1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 60 kDa and the accession number is P06493-1. | |||
TMPY-04463 | CDKL2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus... | |||
TMPY-04450 | CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 109.7 kDa and the accession number is NP_001777.1&NP_00122... | |||
TMPH-01167 | CDK1 Protein, Human, Recombinant (His) | Human | E. coli |
CDK1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01074 | CDC20 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CDC20 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.2 kDa and the accession number is Q12834. | |||
TMPH-01703 | CDC25C Protein, Human, Recombinant (His) | Human | E. coli |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly de... | |||
TMPY-04548 | CDK4 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel... | |||
TMPY-02238 | MAD2L1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 famil... | |||
TMPY-04556 | CDK5 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which... | |||
TMPY-02150 | GADD45A Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulatio... | |||
TMPY-04542 | CDK2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas... |