Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 33.00 | |
10 mg | In stock | $ 45.00 | |
25 mg | In stock | $ 77.00 | |
50 mg | In stock | $ 126.00 | |
100 mg | In stock | $ 207.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. |
Targets&IC50 | CDK4/CyclinD1:850 nM, CDK2/CyclinE:35 nM, Cdc2/CyclinB:4 nM, CDK2/CyclinA:70 nM |
Cell Research | Cells are seeded at 10000 density in 96-well plates and treated with various concentrations of Purvalanol A (0-100 μM) for 24 h. Cells are exposed to 10 μL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet- razolium bromide dye (5 mg/mL) and are incubated at 37℃ for 4 h. In order to solubilize the formazan crystals 100 μL DMSO is added. Absorbance is determined at 570 nm spectrophotometrically.(Only for Reference) |
Synonyms | NG-60 |
Molecular Weight | 388.89 |
Formula | C19H25ClN6O |
CAS No. | 212844-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.9 mg/mL (100 mM)
Ethanol: 19.5 mg/mL (50 mM)
You can also refer to dose conversion for different animals. More
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