Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | Inquiry | |
5 mg | 5 days | Inquiry | |
25 mg | 6-8 weeks | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry | |
1 mL * 10 mM (in DMSO) | 5 days | Inquiry |
Description | KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). |
Targets&IC50 | CLK1:19.7 nM, DYRK1A:55.2 nM, CLK3:530 nM |
In vitro | KH-CB19 showed potent inhibition of CLK1 (IC50: 20 nM), and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as HTF. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls [1]. |
Molecular Weight | 338.19 |
Formula | C15H13Cl2N3O2 |
CAS No. | 1354037-26-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (147.85 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KH-CB19 1354037-26-5 Others KHCB19 KH CB19 KH-CB-19 inhibitor inhibit