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Cat No. | Product Name | Synonyms | Targets |
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T11960 | MBM-55 | GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase | |
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. | |||
T1807 | JW 55 | JW55 | PARP , Wnt/beta-catenin |
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). | |||
TP1926 | WRW4 TFA(878557-55-2 free base) | WRW4 | Others |
WRW4 TFA (878557-55-2 free base) is a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA(878557-55-2 free base) specifically inhibits the increa... | |||
T40548 | NH-3 | Thyroid hormone receptor(THR) | |
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the... | |||
TP1777L | P2Ca acetate(142606-55-1 free base) | Others | |
p2Ca acetate is a naturally processed peptide that derives from a ubiquitous enzyme, alpha-ketoglutarate dehydrogenase, and is recognized in association with the class I MHC protein, Ld, by a CTL clone (2C). | |||
T10215 | AAPK-25 | Apoptosis , PLK , Aurora Kinase | |
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ... | |||
T4039 | BIBB 515 | Others | |
BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of... | |||
T36944 | Ara-G | Nucleoside Antimetabolite/Analog | |
Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate... | |||
T78541 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | MOG (35-55) (TFA) | |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA, a minor constituent of central nervous system (CNS) myelin, demonstrates encephalitogenic properties by inducing T cell proliferation and... | |||
T78542 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate | MOG (35-55) (acetate) | |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate, a minor component of CNS myelin, exhibits encephalitogenic activity by inducing T cell proliferation and a Th1 cytokine response, alo... | |||
T79570 | SARS-CoV-2-IN-55 | SARS-CoV | |
SARS-CoV-2-IN-55 (compound 65) is an inhibitor of SARS-CoV-2 exhibiting low cytotoxicity, characterized by an IC50 of 0.3 μM, effectuated through direct interaction with VSV-S pseudoparticles [1]. | |||
T61274 | PC190723 | ||
PC190723 (Compound 2), an inhibitor of the FtsZ bacterial cell division protein, demonstrates potent efficacy with an IC50 value of 55 ng/ml. Additionally, it showcases notable anti-staphylococcal activity, characterized... | |||
T4246L | Varenicline | ||
Varenicline (CP 526555), a cytisine-based nicotinic ligand, is a potent partial agonist for the α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM and acts as a full agonist for α7 and α3β4 nAChRs... | |||
T79620 | Anti-inflammatory agent 55 | ||
Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of iNOS, TNF-α, IL-6, and IL-1β. It notably suppresses LPS-... | |||
T35422 | 5'-pApA (sodium salt) | ||
5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedvia... | |||
T35695 | Oleic Acid-13C | ||
Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been fo... | |||
T77915 | CCT367766 formic | PROTACs | |
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at... | |||
T35479 | CRBN-6-5-5-VHL | ||
Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. ... | |||
T83688 | R 715 TFA | [Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH | |
R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances... | |||
T35507 | 12-HETE | ||
(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates ne... | |||
T65396 | Piperazine 2HCl | ||
Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspecte... | |||
T37800 | PF-04449613 | ||
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less tha... | |||
T35451 | β-Defensin-2 (human) (trifluoroacetate salt) | ||
β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cari... | |||
T35771 | Destruxin B2 | ||
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg)... | |||
T37469 | Sitamaquine tosylate | ||
Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrog... | |||
T38145 | Eltoprazine | ||
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro... | |||
T35591 | Guanfacine-13C,15N3 | Guanfacine-13C,15N3 | |
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A... | |||
T38106 | JC-171 | ||
JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1]. | |||
T36241 | Arecaidine propargyl ester (hydrobromide) | ||
Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0... | |||
T35426 | β-Defensin-1 (human) (trifluoroacetate salt) | ||
β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus... |
Cat No. | Product Name | Synonyms | Targets |
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T36791 | Lysophosphatidylcholine 18:2 | ||
1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC dec... | |||
T37690 | Phenylpyropene A | ||
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01905 | CD160 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD160 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is O95971-1. | |||
TMPK-00062 | CD160 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. CD160 antigenis a receptor on immune cells capable to... | |||
TMPJ-00063 | CD160 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181... | |||
TMPY-00105 | Recombinant Protein G | E. coli | |
Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate bindi... | |||
TMPK-00164 | IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is invol... | |||
TMPK-00165 | IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is invol... | |||
TMPJ-00028 | CCL2 Protein, Mouse, Recombinant | Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equ... | |||
TMPJ-01178 | TGFBR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho... | |||
TMPY-02032 | FLRT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1... | |||
TMPJ-00054 | PLGF-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF f... | |||
TMPY-01438 | FLRT3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Leucine-rich repeat transmembrane protein FLRT3, also known as Fibronectin-like domain-containing leucine-rich transmembrane protein 3, and FLRT3, is a single-pass type I membrane protein which belongs to the fibronectin... |