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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3887 | Rosarin | Others | |
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice . | |||
T62899 | Tau-aggregation and neuroinflammation-IN-1 | Microtubule Associated , NO Synthase | |
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma... | |||
TJS1779 | Protosappanin A | PTA | NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT |
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory ... | |||
T24161 | IMM-H004 | IMMH 004,IMMH-004,IMMH004 | |
IMM-H004 is an effective inhibitor of BV2 microglia activation. | |||
T4479 | Isomaculosidine | Others | |
Isomaculosidine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. | |||
T10809 | CHPG | Others | |
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway. | |||
T79590 | Anti-neuroinflammation agent 1 | NOD-like Receptor (NLR) | |
Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1]. | |||
TN4182 | Hannokinol | Others | |
(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM. | |||
TN3519 | Bisdehydroneotuberostemonine | Others | |
Bisdehydroneotuberostemonine shows significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 uM. | |||
TN4827 | Preskimmianine | Others | |
Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. | |||
T79930 | Sanggenon A | Sanggenone A | NF-κB |
Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it significantly suppresses Lipopolysaccharide (LPS)-induced nitric... | |||
T74781 | UT-11 | ||
UT-11 is a potent brain-permeable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting IC50 values of 0.10 μM and 2.00 μM for the inhibition of PGE2 production in human (SK-N-AS) and murine (BV2) cell... | |||
TN4465 | Luvangetin | COX , Prostaglandin Receptor , Antifection | |
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rat... | |||
TN5248 | Voleneol | NOS , COX , Prostaglandin Receptor | |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxid... | |||
TN2517 | 1,7-Dihydroxy-2,3-dimethoxyxanthone | Others | |
1,7-Dihydroxy-2,3-dimethoxyxanthone may have medicinal use in the management of inflammation, asthma and allergy, it antagonises in a non competitive but, reversible manner the contractions induced by chemical inflammato... | |||
T5157 | 9,13-Epidioxy-8(14)-abieten-18-oic acid | Others | |
9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potent... | |||
TN5901 | Cudratricusxanthone A | ||
Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to in... | |||
TN3587 | Capillarisin | MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT | |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ... |