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EGFR-IN-12

Catalog No. T5168 CAS 879127-07-8

Synonyms: EGFR Inhibitor

EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.

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EGFR-IN-12, CAS 879127-07-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 75.00
5 mg	In stock	$ 162.00
10 mg	In stock	$ 272.00
25 mg	In stock	$ 547.00
50 mg	In stock	$ 779.00
100 mg	In stock	$ 1,060.00
500 mg	In stock	$ 2,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 177.00

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Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
Targets&IC50	EGFR:21 nM (cell free), EGFR (L858R):63 nM (cell free), EGFR (L861Q):4 nM (cell free)
In vitro	EGFR Inhibitor possesses an enzymatic IC50= 21 nM against EGFR kinase in vitro and blocks receptor autophosphorylation in cells. EGFR Inhibitor also potently inhibits two EGFR mutants associated with clinical response to gefitinib: L858R (IC50: 63 nM) and L861Q (IC50: 4 nM), but displays much weaker activity against Her 4 (IC50: 7640 nM).

Synonyms	EGFR Inhibitor
Molecular Weight	413.4
Formula	C21H18F3N5O
CAS No.	879127-07-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 10 mg/mL

DMSO: 50 mg/mL (120.95 mM)

References and Literature

1. Zhang Q, et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J Am Chem Soc. 2006 Feb 22;128(7):2182-3.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Apoptosis Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max Angiogenesis related Compound Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EGFR-IN-12 879127-07-8 Angiogenesis Apoptosis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR EGFRIN12 autophosphorylation anti-proliferation 4,6-disubstituted antitumor kinases Epidermal growth factor receptor EGFR Inhibitor inhibit EGFR IN 12 AKT pyrimidine ErbB-1 Inhibitor HER1 Tyrosine inhibitor

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