suppression — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.		Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
T21422	Methylnaltrexone bromide	Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728	Opioid Receptor
	Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af...		Opioid Receptor
T7943	Fluphenazine decanoate		Dopamine Receptor
	Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.		Dopamine Receptor
T11174	(R)-Elagolix	NBI-56418	GNRH Receptor
	(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do...		GNRH Receptor
T5788	XYLOBIOSE		IL Receptor , TNF
	XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.		IL Receptor , TNF
T20802	Flumethasone pivalate	Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten	Others
	Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang...		Others
T8400	Pamidronic acid		Wnt/beta-catenin
	Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells		Wnt/beta-catenin
T6S0214	Dl-Maackiain	(+)-Maackiain,Demethylpterocarpin	Apoptosis , Parasite
	1. dl-Maackiain (Demethylpterocarpin) induces apoptosis and growth suppression 2. MAK1 is the second functional gene cloned from Maackiain detoxification.		Apoptosis , Parasite
T5665	Geraniol		Others , Endogenous Metabolite , Antifungal
	geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.		Others , Endogenous Metabolite , Antifungal
T4981	Anisotropine Methylbromide		Prostaglandin Receptor , AChR
	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.		Prostaglandin Receptor , AChR
T60098	MSC2504877	3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one	Others
	MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos...		Others
T2498	Adjudin	AF-2364	Chloride channel , Mitochondrial Metabolism
	Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.		Chloride channel , Mitochondrial Metabolism
T6S1367	Procyanidin B2	Proanthocyanidin B2	Reactive Oxygen Species , NOD
	Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ...		Reactive Oxygen Species , NOD
T9953	BT173		Others
	BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.		Others
T5785	MALTOTETRAOSE	Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose	TNF , Endogenous Metabolite
	Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development.		TNF , Endogenous Metabolite
T13974	ZL0580		Epigenetic Reader Domain , HIV Protease
	ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.		Epigenetic Reader Domain , HIV Protease
T11079	NMI 8739	n-docosahexaenoyl dopamine,Dha-DA conjugate	Dopamine Receptor
	NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.		Dopamine Receptor
T13360	XRK3F2		Autophagy
	XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.		Autophagy
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T1721	2'-Deoxyuridine	Uracil deoxyriboside,2-deoxyuridine,2'-dU	Others , DNA/RNA Synthesis , Endogenous Metabolite
	2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12...		Others , DNA/RNA Synthesis , Endogenous Metabolite