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Methylnaltrexone bromide

Catalog No. T21422 CAS 73232-52-7

Synonyms: Relistor, MOA-728, MOA 728, Methylnaltrexone, MOA728

Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Methylnaltrexone bromide Chemical Structure

Methylnaltrexone bromide, CAS 73232-52-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 47.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 200.00
50 mg	In stock	$ 286.00
100 mg	In stock	$ 497.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 99.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Relistor, MOA-728, MOA 728, Methylnaltrexone, MOA728
Molecular Weight	436.35
Formula	C21H26BrNO4
CAS No.	73232-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 60 mg/ml (137.5 mM)

References and Literature

1. Rauck RL. Treatment of opioid-induced constipation: focus on the peripheral μ-opioid receptor antagonist methylnaltrexone. Drugs. 2013 Aug;73(12):1297-306. doi: 10.1007/s40265-013-0084-5. Review. PubMed PMID: 23881667. 2. Grover M, Camilleri M. Treatment with Methylnaltrexone and IVIG for Paraneoplastic Gastrointestinal Dysmotility. Gastroenterol Hepatol (N Y). 2013 Jan;9(1):51-3. Review. PubMed PMID: 24707236; PubMed Central PMCID: PMC3975980. 3. Bader S, Dürk T, Becker G. Methylnaltrexone for the treatment of opioid-induced constipation. Expert Rev Gastroenterol Hepatol. 2013 Jan;7(1):13-26. doi: 10.1586/egh.12.63. Review. PubMed PMID: 23265145.

Citations

1. Liu X, Yang J, Yang C, et al. Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway. Cancer Cell International. 2021, 21(1): 1-14 2. Liu X, Yang J, Yang C, et al. Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway. Cancer cell International. 2021, 21(1): 1-14

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library GPCR Compound Library EMA Approved Drug Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library FDA-Approved Drug Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methylnaltrexone bromide 73232-52-7 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibit suppression gastrointestinal blood-brain tract Relistor peripheral Methylnaltrexone Bromide barrier MOA-728 analgesia MOA 728 Methylnaltrexone Inhibitor MOA728 inhibitor

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