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XRK3F2

Catalog No. T13360 CAS 2375193-43-2

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

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XRK3F2, CAS 2375193-43-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 236.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 559.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98.91%

Purity: 98.75%

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Description

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

In vitro

XRK3F2 inhibits p62-ZZ domain signaling and rescues Myeloma-induced Gfi1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression. XRK3F2 prevents MM-induced upregulation of Gfi1 and repression of the Runx2 gene when present in MM-preOB co-cultures. p62-ZZ-domain blocking by XRK3F2 prevents MM conditioned media and TNF plus IL7-mediated Gfi1 mRNA upregulation and the concomitant Runx2 repression. XRK3F2 decreased MM-induced GFI1 occupancy at the Runx2-P1 promoter and prevented recruitment of HDAC1, thus preserving the transcriptionally permissive chromatin mark H3K9ac on Runx2 and allowing osteogenic differentiation[1].

Molecular Weight	435.89
Formula	C23H24ClF2NO3
CAS No.	2375193-43-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135.0 mg/mL (309.7 mM), Sonication is recommended.

H2O: 0.8 mg/mL (1.9 mM), Sonication is recommended.

References and Literature

1. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.

Citations

1. Xu Y, Zhu C, Zhu C, et al.SQSTM1/p62 promotes the progression of gastric cancer through epithelial-mesenchymal transition.Heliyon.2024

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max Autophagy Compound Library Bioactive Compound Library

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Keywords

XRK3F2 2375193-43-2 Autophagy XRK-3F2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.